TY - JOUR
T1 - Epidemiology of influenza C virus in man
T2 - Multiple evolutionary lineages and low rate of change
AU - Buonagurio, Deborah A.
AU - Nakada, Susumu
AU - Fitch, Walter M.
AU - Palese, Peter
N1 - Funding Information:
We thank Dr. Ulrich Desselhergerf or helpful discussions. The virus strains used in this study were kindly provided by Dr. P. Chakraverty (C/ENG/83), Dr. W. Dowdle (C/GL/54), Dr. A. P. Kendal (C/MS/ 80),D r. H. F. Maassab (C/AA/W), Dr. K. Nakamura (C/YA/81), Dr. R. J. O’Callaghan (C/JHG/66), and Dr. J. M. Zhu (C/TAY/47). This work was supported in part by Public Health Service Grants AI-11823( P.P.) and AI-18998( P.P.) from the National Institutes of Health, and National ScienceF oundation Grant BSR-8400682( W.M.F.). The oligonucleotides were synthesizedo n an automatedD NA synthesizer purchasedt hrough an NSF equipmentg rant.
PY - 1986/8
Y1 - 1986/8
N2 - The nucleotide sequences of nonstructural protein (NS) genes of human influenza C viruses isolated between 1947 and 1983 were determined and compared. Assuming constant evolutionary rates, the extent of nucleotide differences among NS genes does not correspond to the isolation years of the strains. This suggests that more than one gene lineage is present in the population. Furthermore, examination of the eight C virus NS gene sequences by the maximum parsimony method (W. M. Fitch, 1971, Syst. Zool. 20, 406-416) yielded phylogenetic trees that were grossly different from those obtained using the hemagglutinin genes for the same eight isolates. This result is compatible with the idea of reassortment of genes in nature across lineages of influenza C viruses. The sequence analysis also suggests that nucleotide substitutions occur at a lower rate in the C virus NS genes than in influenza A virus NS genes.
AB - The nucleotide sequences of nonstructural protein (NS) genes of human influenza C viruses isolated between 1947 and 1983 were determined and compared. Assuming constant evolutionary rates, the extent of nucleotide differences among NS genes does not correspond to the isolation years of the strains. This suggests that more than one gene lineage is present in the population. Furthermore, examination of the eight C virus NS gene sequences by the maximum parsimony method (W. M. Fitch, 1971, Syst. Zool. 20, 406-416) yielded phylogenetic trees that were grossly different from those obtained using the hemagglutinin genes for the same eight isolates. This result is compatible with the idea of reassortment of genes in nature across lineages of influenza C viruses. The sequence analysis also suggests that nucleotide substitutions occur at a lower rate in the C virus NS genes than in influenza A virus NS genes.
UR - https://www.scopus.com/pages/publications/0022496652
U2 - 10.1016/0042-6822(86)90003-6
DO - 10.1016/0042-6822(86)90003-6
M3 - Article
C2 - 2943076
AN - SCOPUS:0022496652
SN - 0042-6822
VL - 153
SP - 12
EP - 21
JO - Virology
JF - Virology
IS - 1
ER -