Epidemiology of Gastric Malignancies 2000–2018 According to Histology: A Population-Based Analysis of Incidence and Temporal Trends

Sheila D. Rustgi, Meg McKinley, Brandon McBay, Haley M. Zylberberg, Scarlett L. Gomez, Chin Hur, Fay Kastrinos, Samir Gupta, Michelle Kang Kim, Steven H. Itzkowitz, Shailja C. Shah

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Background & Aims: Gastric cancer (GC) remains a leading cause of cancer and cancer-related mortality. Recent reports suggest noncardia GC is increasing in certain U.S. populations. However, whether these trends are driven by gastric adenocarcinoma (GA) or other histologies, including neuroendocrine tumors (NETs), lymphoma, or gastrointestinal stromal tumors (GISTs), is unclear. Methods: We analyzed the Surveillance, Epidemiology and End Results-18 cancer registry (2000–2018) to determine age-standardized incidence rates (ASIR) and annual percentage change (APC) trends for histologically-confirmed GCs, stratified by anatomic location (noncardia vs cardia), age group (20–49 vs 50+ years), sex, race, and ethnicity. Joinpoint regression modeling estimated the statistical significance of trend comparisons. Results: Of 74,520 individuals with noncardia GC, most (66.2%) were GA, with the next largest categories being non–mucosa-associated lymphoid tissue (non-MALT) lymphomas (6.9%), GIST (6.7%), NET (6.4%), and MALT lymphoma (5.6%). Noncardia GA ASIR was significantly higher than other histologies and demonstrated the greatest differences by race and ethnicity. APCs for GA and MALT, both Helicobacter pylori–associated cancers, declined significantly over time, which was driven primarily by trends among individuals ≥50 years-old. NET and GIST APCs significantly increased irrespective of age group, with the highest APCs observed among non-Hispanic white individuals. Cardia GC was rarer than noncardia GC and comprised primarily by GA (87.9%). Cardia GC incidence fell during the study period, which was primarily driven by decline in cardia GA. Conclusions: GA was the most common histology. On the basis of our findings, the rise in noncardia GC among certain U.S. populations appears predominantly driven by NET and GIST, not GA. Further studies are needed to clarify underlying etiologies for these findings.

Original languageEnglish
Pages (from-to)3285-3295.e8
JournalClinical Gastroenterology and Hepatology
Volume21
Issue number13
DOIs
StatePublished - Dec 2023

Keywords

  • Adenocarcinoma
  • Carcinoid
  • Ethnic and Racial Minorities
  • Gastric Neoplasm
  • Helicobacter pylori

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