Epidemiology and Genetic Risk Factors of Drug Hepatotoxicity

Jawad Ahmad; Joseph A. Odin

doi:10.1016/j.cld.2016.08.004

Epidemiology and Genetic Risk Factors of Drug Hepatotoxicity

Jawad Ahmad
, Joseph A. Odin

Research output: Contribution to journal › Review article › peer-review

37 Scopus citations

Abstract

Idiosyncratic drug-induced liver injury (DILI) from prescription medications and herbal and dietary supplements has an annual incidence rate of approximately 20 cases per 100,000 per year. However, the risk of DILI varies greatly according to the drug. In the United States and Europe, antimicrobials are the commonest implicated agents, with amoxicillin/clavulanate the most common, whereas in Asian countries, herbal and dietary supplements predominate. Genetic analysis of DILI is currently limited, but multiple polymorphisms of human leukocyte antigen genes and genes involved in drug metabolism and transport have been identified as risk factors for DILI.

Original language	English
Pages (from-to)	55-72
Number of pages	18
Journal	Clinics in Liver Disease
Volume	21
Issue number	1
DOIs	https://doi.org/10.1016/j.cld.2016.08.004
State	Published - 1 Feb 2017

Keywords

Drug-induced liver injury (DILI)
Epidemiology
Genetics

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title = "Epidemiology and Genetic Risk Factors of Drug Hepatotoxicity",

abstract = "Idiosyncratic drug-induced liver injury (DILI) from prescription medications and herbal and dietary supplements has an annual incidence rate of approximately 20 cases per 100,000 per year. However, the risk of DILI varies greatly according to the drug. In the United States and Europe, antimicrobials are the commonest implicated agents, with amoxicillin/clavulanate the most common, whereas in Asian countries, herbal and dietary supplements predominate. Genetic analysis of DILI is currently limited, but multiple polymorphisms of human leukocyte antigen genes and genes involved in drug metabolism and transport have been identified as risk factors for DILI.",

keywords = "Drug-induced liver injury (DILI), Epidemiology, Genetics",

author = "Jawad Ahmad and Odin, \{Joseph A.\}",

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AU - Ahmad, Jawad

AU - Odin, Joseph A.

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Idiosyncratic drug-induced liver injury (DILI) from prescription medications and herbal and dietary supplements has an annual incidence rate of approximately 20 cases per 100,000 per year. However, the risk of DILI varies greatly according to the drug. In the United States and Europe, antimicrobials are the commonest implicated agents, with amoxicillin/clavulanate the most common, whereas in Asian countries, herbal and dietary supplements predominate. Genetic analysis of DILI is currently limited, but multiple polymorphisms of human leukocyte antigen genes and genes involved in drug metabolism and transport have been identified as risk factors for DILI.

AB - Idiosyncratic drug-induced liver injury (DILI) from prescription medications and herbal and dietary supplements has an annual incidence rate of approximately 20 cases per 100,000 per year. However, the risk of DILI varies greatly according to the drug. In the United States and Europe, antimicrobials are the commonest implicated agents, with amoxicillin/clavulanate the most common, whereas in Asian countries, herbal and dietary supplements predominate. Genetic analysis of DILI is currently limited, but multiple polymorphisms of human leukocyte antigen genes and genes involved in drug metabolism and transport have been identified as risk factors for DILI.

KW - Drug-induced liver injury (DILI)

KW - Epidemiology

KW - Genetics

UR - https://www.scopus.com/pages/publications/84991244844

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DO - 10.1016/j.cld.2016.08.004

M3 - Review article

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SN - 1089-3261

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SP - 55

EP - 72

JO - Clinics in Liver Disease

JF - Clinics in Liver Disease

IS - 1

ER -

Epidemiology and Genetic Risk Factors of Drug Hepatotoxicity

Abstract

Keywords

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