Epidemiology and Genetic Risk Factors of Drug Hepatotoxicity

Jawad Ahmad, Joseph A. Odin

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations

Abstract

Idiosyncratic drug-induced liver injury (DILI) from prescription medications and herbal and dietary supplements has an annual incidence rate of approximately 20 cases per 100,000 per year. However, the risk of DILI varies greatly according to the drug. In the United States and Europe, antimicrobials are the commonest implicated agents, with amoxicillin/clavulanate the most common, whereas in Asian countries, herbal and dietary supplements predominate. Genetic analysis of DILI is currently limited, but multiple polymorphisms of human leukocyte antigen genes and genes involved in drug metabolism and transport have been identified as risk factors for DILI.

Original languageEnglish
Pages (from-to)55-72
Number of pages18
JournalClinics in Liver Disease
Volume21
Issue number1
DOIs
StatePublished - 1 Feb 2017

Keywords

  • Drug-induced liver injury (DILI)
  • Epidemiology
  • Genetics

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