Ephaptic conduction in a cardiac strand model with 3D electrodiffusion

Yoichiro Mori, Glenn I. Fishman, Charles S. Peskin

Research output: Contribution to journalArticlepeer-review

117 Scopus citations


We study cardiac action potential propagation under severe reduction in gap junction conductance. We use a mathematical model of cellular electrical activity that takes into account both three-dimensional geometry and ionic concentration effects. Certain anatomical and biophysical parameters are varied to see their impact on cardiac action potential conduction velocity. This study uncovers quantitative features of ephaptic propagation that differ from previous studies based on one-dimensional models. We also identify a mode of cardiac action potential propagation in which the ephaptic and gap-junction-mediated mechanisms alternate. Our study demonstrates the usefulness of this modeling approach for electrophysiological systems especially when detailed membrane geometry plays an important role.

Original languageEnglish
Pages (from-to)6463-6468
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number17
StatePublished - 29 Apr 2008
Externally publishedYes


  • 3D model of electrophysiology
  • Ephaptic coupling
  • Gap junction


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