Environmentally Not So Friendly: Global Warming, Air Pollution, and Wildfires: JACC Focus Seminar, Part 1

Mark R. Miller, Philip J. Landrigan, Manish Arora, David E. Newby, Thomas Münzel, Jason C. Kovacic

Research output: Contribution to journalReview articlepeer-review


Environmental stresses are increasingly recognized as significant risk factors for adverse health outcomes. In particular, various forms of pollution and climate change are playing a growing role in promoting noncommunicable diseases, especially cardiovascular disease. Given recent trends, global warming and air pollution are now associated with substantial cardiovascular morbidity and mortality. As a vicious cycle, global warming increases the occurrence, size, and severity of wildfires, which are significant sources of airborne particulate matter. Exposure to wildfire smoke is associated with cardiovascular disease, and these effects are underpinned by mechanisms that include oxidative stress, inflammation, impaired cardiac function, and proatherosclerotic effects in the circulation. In the first part of a 2-part series on pollution and cardiovascular disease, this review provides an overview of the impact of global warming and air pollution, and because of recent events and emerging trends specific attention is paid to air pollution caused by wildfires.

Original languageEnglish
Pages (from-to)2291-2307
Number of pages17
JournalJournal of the American College of Cardiology
Issue number23
StatePublished - 11 Jun 2024


  • cardiovascular disease
  • light pollution
  • noise pollution
  • soil pollution
  • water pollution


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