Environmental exposures: Evolving evidence for their roles in adult allergic disorders

Kaoru Harada, Rachel L. Miller

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Purpose of review: Allergic disorders are the result of complex interactions between genetic predisposition and environmental exposures. Elucidating how specific environmental exposures contribute to allergic diseases in adults is crucial, especially as the world population ages in a rapidly changing environment. Recent findings: The effects of environmental exposures on allergic diseases remain understudied in adults. Although epidemiological studies suggest various environmental exposures are associated with the development and exacerbation of allergic diseases, further longitudinal studies are needed across various age groups in adults to pinpoint the exposures of concerns and the time windows of susceptibility. Mechanistic studies in adults are few. A multicomponent strategy targeting several allergens has been conditionally recommended for asthma, but recent findings on mitigation strategies remain limited. Summary: Further research on how environmental exposures cause and exacerbate allergic disorders is needed in adults, particularly across disease phenotypes. The effects of mitigation strategies against environmentally induced adult allergic diseases remain large research gaps. A better understanding of how and which environmental exposures contribute to allergic disorders is necessary to identify patients who are at higher risk and would benefit from specific interventions.

Original languageEnglish
Pages (from-to)24-28
Number of pages5
JournalCurrent Opinion in Allergy and Clinical Immunology
Volume22
Issue number1
DOIs
StatePublished - 2022

Keywords

  • Air pollution
  • chemicals
  • environmental exposure
  • exposome

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