TY - JOUR
T1 - Environmental exposures and pediatric kidney function and disease
T2 - A systematic review
AU - Zheng, Laura Y.
AU - Sanders, Alison P.
AU - Saland, Jeffrey M.
AU - Wright, Robert O.
AU - Arora, Manish
N1 - Funding Information:
This work was supported in part by funding from the NIH: T32HD049311, P30ES23515, R01ES013744, R01ES020268, R01ES021357, R01ES026033, DP2ES025453, and UG3OD023337.
Publisher Copyright:
© 2017
PY - 2017
Y1 - 2017
N2 - Background Environmental chemical exposures have been implicated in pediatric kidney disease. No appraisal of the available evidence has been conducted on this topic. Methods We performed a systematic review of the epidemiologic studies that assessed association of environmental exposures with measures of kidney function and disease in pediatric populations. The search period went through July 2016. Results We found 50 studies that met the search criteria and were included in this systematic review. Environmental exposures reviewed herein included lead, cadmium, mercury, arsenic, fluoride, aflatoxin, melamine, environmental tobacco, bisphenol A, dental procedures, phthalates, ferfluorooctanoic acid, triclosan, and thallium/uranium. Most studies assessed environmental chemical exposure via biomarkers but four studies assessed exposure via proximity to emission source. There was mixed evidence of association between metal exposures, and other non-metal environmental exposures and pediatric kidney disease and other kidney disease biomarkers. The evaluation of causality is hampered by the small numbers of studies for each type of environmental exposure, as well as lack of study quality and limited prospective evidence. Conclusion There is a need for well-designed epidemiologic studies of environmental chemical exposures and kidney disease outcomes.
AB - Background Environmental chemical exposures have been implicated in pediatric kidney disease. No appraisal of the available evidence has been conducted on this topic. Methods We performed a systematic review of the epidemiologic studies that assessed association of environmental exposures with measures of kidney function and disease in pediatric populations. The search period went through July 2016. Results We found 50 studies that met the search criteria and were included in this systematic review. Environmental exposures reviewed herein included lead, cadmium, mercury, arsenic, fluoride, aflatoxin, melamine, environmental tobacco, bisphenol A, dental procedures, phthalates, ferfluorooctanoic acid, triclosan, and thallium/uranium. Most studies assessed environmental chemical exposure via biomarkers but four studies assessed exposure via proximity to emission source. There was mixed evidence of association between metal exposures, and other non-metal environmental exposures and pediatric kidney disease and other kidney disease biomarkers. The evaluation of causality is hampered by the small numbers of studies for each type of environmental exposure, as well as lack of study quality and limited prospective evidence. Conclusion There is a need for well-designed epidemiologic studies of environmental chemical exposures and kidney disease outcomes.
KW - Children
KW - Environmental exposures
KW - Epidemiology
KW - Kidney disease
KW - Metals
UR - http://www.scopus.com/inward/record.url?scp=85024494817&partnerID=8YFLogxK
U2 - 10.1016/j.envres.2017.06.029
DO - 10.1016/j.envres.2017.06.029
M3 - Review article
C2 - 28727988
AN - SCOPUS:85024494817
SN - 0013-9351
VL - 158
SP - 625
EP - 648
JO - Environmental Research
JF - Environmental Research
ER -