Environmental epigenetics and asthma: Current concepts and call for studies

Rachel L. Miller, Shuk Mei Ho

Research output: Contribution to journalReview articlepeer-review

246 Scopus citations


Recent studies suggest that epigenetic regulation (heritable changes in gene expression that occur in the absence of alterations in DNA sequences) may in part mediate the complex gene-by-environment interactions that can lead to asthma. The variable natural history of asthma (i.e., incidence and remission of symptoms) may be a result of epigenetic changes, such as DNA methylation, covalent histone modifications, microRNA changes, and chromatin alterations, after early or later environmental exposures. Findings from multiple epidemiologic and experimental studies indicate that asthma risk may be modified by epigenetic regulation. One study suggested that the transmission of asthma risk may occur across multiple generations. Experimental studies provide substantial in vitro data indicating that DNA methylation of genes critical to T-helper cell differentiation may induce polarization toward or away from an allergic phenotype. Despite this initial progress, fundamental questions remain that need to be addressed by well-designed research studies. Data generated from controlled experiments using in vivo models and/or clinical specimens collected after environmental exposure monitoring are limited. Importantly, cohort-driven epigenetic research has the potential to address key questions, such as those concerning the influence of timing of exposure, dose of exposure, diet, and ethnicity on susceptibility to asthma development. There is immense promise that the study of environmental epigenetics will help us understand a theoretically preventable environmental disease.

Original languageEnglish
Pages (from-to)567-573
Number of pages7
JournalAmerican Journal of Respiratory and Critical Care Medicine
Issue number6
StatePublished - 15 Mar 2008
Externally publishedYes


  • Asthma
  • DNA methylation
  • Epigenetics
  • Gene-environment interactions


Dive into the research topics of 'Environmental epigenetics and asthma: Current concepts and call for studies'. Together they form a unique fingerprint.

Cite this