Enteric viruses evoke broad host immune responses resembling those elicited by the bacterial microbiome

Simone Dallari, Thomas Heaney, Adriana Rosas-Villegas, Jessica A. Neil, Serre Yu Wong, Judy J. Brown, Kelly Urbanek, Christin Herrmann, Daniel P. Depledge, Terence S. Dermody, Ken Cadwell

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


The contributions of the viral component of the microbiome—the virome—to the development of innate and adaptive immunity are largely unknown. Here, we systematically defined the host response in mice to a panel of eukaryotic enteric viruses representing six different families. Infections with most of these viruses were asymptomatic in the mice, the magnitude and duration of which was dependent on the microbiota. Flow cytometric and transcriptional profiling of mice mono-associated with these viruses unveiled general adaptations by the host, such as lymphocyte differentiation and IL-22 signatures in the intestine, as well as numerous viral-strain-specific responses that persisted. Comparison with a dataset derived from analogous bacterial mono-association in mice identified bacterial species that evoke an immune response comparable with the viruses we examined. These results expand an understanding of the immune space occupied by the enteric virome and underscore the importance of viral exposure events.

Original languageEnglish
Pages (from-to)1014-1029.e8
JournalCell Host and Microbe
Issue number6
StatePublished - 9 Jun 2021


  • enteric virome
  • host-virome relationship
  • regulation of the enteric immune system
  • virome
  • virus


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