Enlarged perivascular spaces and plasma Aβ42/Aβ40 ratio in older adults without dementia

Arunima Kapoor, Aimée Gaubert, Belinda Yew, Jung Yun Jang, Shubir Dutt, Yanrong Li, John Paul M. Alitin, Amy Nguyen, Jean K. Ho, Anna E. Blanken, Isabel J. Sible, Anisa Marshall, Fatemah Shenasa, Kathleen E. Rodgers, Alessandra C. Martini, Elizabeth Head, Daniel A. Nation

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Dilation of perivascular spaces (PVS) in the brain may indicate poor fluid drainage due to the accumulation of perivascular cell debris, waste, and proteins, including amyloid-beta (Aβ). No prior study has assessed whether plasma Aβ levels are related to PVS in older adults without dementia. Independently living older adults (N = 56, mean age = 68.2 years; Standard deviation (SD) = 6.5; 30.4% male) free of dementia or clinical stroke were recruited from the community and underwent brain MRI and venipuncture. PVS were qualitatively scored and dichotomized to low PVS burden (scores 0–1,) or high PVS burden (score>1). Plasma was assayed using a Quanterix Simoa Kit to quantify Aβ42 and Aβ40 levels. A significant difference was observed in plasma Aβ42/Aβ40 ratio between low and high PVS burden, controlling for age (F[1, 53] = 5.59, p = 0.022, η2 = 0.10), with lower Aβ42/Aβ40 ratio in the high PVS burden group. Dilation of PVS is associated with a lower plasma Aβ42/Aβ40 ratio, which may indicate higher cortical amyloid deposition. Future longitudinal studies examining PVS changes, and the pathogenesis of AD are warranted.

Original languageEnglish
Pages (from-to)43-48
Number of pages6
JournalNeurobiology of Aging
Volume128
DOIs
StatePublished - Aug 2023
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Aβ42/Aβ40 Ratio
  • Perivascular spaces
  • Small vessel disease
  • Vascular cognitive impairment

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