ENIGMA pediatric msTBI: Preliminary results from meta-analysis of diffusion MRI

Emily L. Dennis, Karen Caeyenberghs, Talin Babikian, Alexander Olsen, Christopher C. Giza, Robert F. Asarnow, Harvey Levin, Peter Kochunov, Neda Jahanshad, Paul M. Thompson, David Tate, Elisabeth Wilde

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Traumatic brain injury (TBI) is a major public health issue around the world. Pediatric TBI patients are at risk of long-term disabilities, as a brain injury sustained during development can affect on-going maturational processes. The white matter (WM) in particular is vulnerable, as myelination continues into the third decade of life and beyond, and poor myelination of tracts can result in decreased integration within brain networks. In addition, variability and heterogeneity are hallmarks of TBI, e.g., injury-related variables and symptoms. These issues combined with small sample sizes limit the power and generalizability of individual studies. In the present study, we employed a meta-analytic approach, combining data across 4 pediatric TBI samples resulting in 104 TBI (75M/29F) and 114 control participants (70M/44F) between 7-18 years, using harmonized processing and analysis as part of the ENIGMA consortium (Enhancing NeuroImaging Genetics through Meta-Analysis). We report lower fractional anisotropy (FA) values in TBI patients across several post-injury windows, particularly in central WM tracts. Within the TBI patient group, we also report marginally significant results of lower FA in younger TBI patients, patients scanned closer to time of injury, and female patients. Although this meta-analytic approach yielded the largest sample size reported yet in pediatric moderate/severe TBI (msTBI) neuroimaging, our trends indicate that larger sample sizes are needed in further studies. As additional cohorts join the ENIGMA Pediatric moderate/severe TBI (msTBI) effort, more robust effects will be revealed.

Original languageEnglish
Title of host publication14th International Symposium on Medical Information Processing and Analysis
EditorsNatasha Lepore, Eduardo Romero, Jorge Brieva
ISBN (Electronic)9781510626058
StatePublished - 2018
Externally publishedYes
Event14th International Symposium on Medical Information Processing and Analysis, SIPAIM 2018 - Mazatlan, Mexico
Duration: 24 Oct 201826 Oct 2018

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X


Conference14th International Symposium on Medical Information Processing and Analysis, SIPAIM 2018


  • diffusion magnetic resonance imaging (dMRI)
  • metaanalysis
  • pediatric
  • traumatic brain injury (TBI)


Dive into the research topics of 'ENIGMA pediatric msTBI: Preliminary results from meta-analysis of diffusion MRI'. Together they form a unique fingerprint.

Cite this