TY - JOUR
T1 - Enhancement of Memory by Physostigmine
AU - Davis, Kenneth L.
AU - Mohs, Richard C.
AU - Tinklenberg, Jared R.
PY - 1979/10/25
Y1 - 1979/10/25
N2 - To the Editor: A deficit in central cholinergic function has been implicated in age-related memory loss and Alzheimer's disease.1,2 We wish to report that we have been able to improve memory performance in six elderly patients by administering physostigmine, a cholinesterase inhibitor that, as we previously demonstrated, can improve memory in young adults.3 A critical feature of our study in elderly patients is that each was given several doses of physostigmine in an effort to determine a dose that would improve memory. This drug improves memory only in a narrow, low-dose range,4 and the dose that improves memory may vary. No extract is available for articles shorter than 400 words.
AB - To the Editor: A deficit in central cholinergic function has been implicated in age-related memory loss and Alzheimer's disease.1,2 We wish to report that we have been able to improve memory performance in six elderly patients by administering physostigmine, a cholinesterase inhibitor that, as we previously demonstrated, can improve memory in young adults.3 A critical feature of our study in elderly patients is that each was given several doses of physostigmine in an effort to determine a dose that would improve memory. This drug improves memory only in a narrow, low-dose range,4 and the dose that improves memory may vary. No extract is available for articles shorter than 400 words.
UR - https://www.scopus.com/pages/publications/0018567466
U2 - 10.1056/NEJM197910253011721
DO - 10.1056/NEJM197910253011721
M3 - Letter
C2 - 481551
AN - SCOPUS:0018567466
SN - 0028-4793
VL - 301
SP - 946
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 17
ER -