Engineering regional diversity: A morphogen screen for patterned brain organoids

Georgia Panagiotakos; Nan Yang

doi:10.1016/j.stem.2024.11.007

Engineering regional diversity: A morphogen screen for patterned brain organoids

Nash Family Department of Neuroscience

Research output: Contribution to journal › Comment/debate

Abstract

Morphogens orchestrate cellular diversity during nervous system development, yet a systematic approach to harnessing these signals in stem cell differentiation remains elusive. Amin et al.¹ present a platform integrating parallel morphogen modulator screening with single-cell sequencing of neural organoids, reinforcing brain regionalization principles and enabling detailed cellular annotation.

Original language	English
Pages (from-to)	1724-1726
Number of pages	3
Journal	Cell Stem Cell
Volume	31
Issue number	12
DOIs	https://doi.org/10.1016/j.stem.2024.11.007
State	Published - 5 Dec 2024

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title = "Engineering regional diversity: A morphogen screen for patterned brain organoids",

abstract = "Morphogens orchestrate cellular diversity during nervous system development, yet a systematic approach to harnessing these signals in stem cell differentiation remains elusive. Amin et al.1 present a platform integrating parallel morphogen modulator screening with single-cell sequencing of neural organoids, reinforcing brain regionalization principles and enabling detailed cellular annotation.",

author = "Georgia Panagiotakos and Nan Yang",

note = "Publisher Copyright: {\textcopyright} 2024 Elsevier Inc.",

year = "2024",

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language = "English",

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T1 - Engineering regional diversity

T2 - A morphogen screen for patterned brain organoids

AU - Panagiotakos, Georgia

AU - Yang, Nan

PY - 2024/12/5

Y1 - 2024/12/5

N2 - Morphogens orchestrate cellular diversity during nervous system development, yet a systematic approach to harnessing these signals in stem cell differentiation remains elusive. Amin et al.1 present a platform integrating parallel morphogen modulator screening with single-cell sequencing of neural organoids, reinforcing brain regionalization principles and enabling detailed cellular annotation.

AB - Morphogens orchestrate cellular diversity during nervous system development, yet a systematic approach to harnessing these signals in stem cell differentiation remains elusive. Amin et al.1 present a platform integrating parallel morphogen modulator screening with single-cell sequencing of neural organoids, reinforcing brain regionalization principles and enabling detailed cellular annotation.

UR - https://www.scopus.com/pages/publications/85210384617

U2 - 10.1016/j.stem.2024.11.007

DO - 10.1016/j.stem.2024.11.007

M3 - Comment/debate

AN - SCOPUS:85210384617

SN - 1934-5909

VL - 31

SP - 1724

EP - 1726

JO - Cell Stem Cell

JF - Cell Stem Cell

IS - 12

ER -

Engineering regional diversity: A morphogen screen for patterned brain organoids

Abstract

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