Engineering protein activity and stability through control of the nanoscale environment

Jonathan S. Dordick, Prashanth Asuri, Sandeep S. Karajanagi, Ravi S. Kane

Research output: Contribution to conferencePaperpeer-review

Abstract

We have discovered a novel property of nanomaterials - their ability to enhance protein activity and stability. We report that single-walled carbon nanotubes (SWNTs) can significantly enhance enzyme function and stability in strongly denaturing environments. The enhanced stability was exploited in the preparation of highly stable and active nanocomposite films that completely resist nonspecific protein adsorption. The protein-nanotube conjugates represent a new generation of highly selective, active, and stable catalytic materials. Furthermore, we will show that by interfacing proteins with nanomaterials a range of applications can be considered including biosensing, diagnostics, vaccines, drug discovery, and drug delivery.

Original languageEnglish
Pages14272
Number of pages1
StatePublished - 2005
Event05AIChE: 2005 AIChE Annual Meeting and Fall Showcase - Cincinnati, OH, United States
Duration: 30 Oct 20054 Nov 2005

Conference

Conference05AIChE: 2005 AIChE Annual Meeting and Fall Showcase
Country/TerritoryUnited States
CityCincinnati, OH
Period30/10/054/11/05

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