Engineered nanoclay based bone-mimetic 3d in vitro test-bed for bone metastasis of breast cancer

Sumanta Kar, Kalpana S. Katti, Dinesh R. Katti

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

Statement of Purpose: Breast cancer (BrCa) is the second leading cause of cancer death in women, after lung cancer. Metastatic breast cancer preferentially spreads to bone and colonizes within the bone marrow to cause bone metastases. To date, the mechanisms of breast cancer-related metastasis to bone are poorly understood, partly due to the overreliance on in vivo xenografts. Recent studies have shed light on the fact that these xenografts did not have not a human bone microenvironment which increasingly considered to be the critical component of metastases. Lack of availability of human bone metastasis samples is also an important issue. To address this drawback, we have developed a nanoclay based 3D in vitro model of breast cancer bone metastasis using human mesenchymal stem cells (MSCs) and human breast cancer cells (BrCa) as a testbed which mimics later stage of breast cancer pathogenesis at the metastatic site.

Original languageEnglish
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Pages641
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - 2019
Externally publishedYes
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: 3 Apr 20196 Apr 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Country/TerritoryUnited States
CitySeattle
Period3/04/196/04/19

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