Engineered matrices for skeletal muscle satellite cell engraftment and function

Woojin M. Han, Young C. Jang, Andrés J. García

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

Regeneration of traumatically injured skeletal muscles is severely limited. Moreover, the regenerative capacity of skeletal muscle declines with aging, further exacerbating the problem. Recent evidence supports that delivery of muscle satellite cells to the injured muscles enhances muscle regeneration and reverses features of aging, including reduction in muscle mass and regenerative capacity. However, direct delivery of satellite cells presents a challenge at a translational level due to inflammation and donor cell death, motivating the need to develop engineered matrices for muscle satellite cell delivery. This review will highlight important aspects of satellite cell and their niche biology in the context of muscle regeneration, and examine recent progresses in the development of engineered cell delivery matrices designed for skeletal muscle regeneration. Understanding the interactions of muscle satellite cells and their niche in both native and engineered systems is crucial to developing muscle pathology-specific cell- and biomaterial-based therapies.

Original languageEnglish
Pages (from-to)96-109
Number of pages14
JournalMatrix Biology
Volume60-61
DOIs
StatePublished - 1 Jul 2017
Externally publishedYes

Keywords

  • Aging
  • Biomaterial
  • Extracellular matrix
  • Niche
  • Satellite cells
  • Skeletal muscle
  • Stem cell therapy

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