Energy metabolism in neuronal/glial induction and in iPSC models of brain disorders

Barbara Mlody; Carmen Lorenz; Gizem Inak; Alessandro Prigione

doi:10.1016/j.semcdb.2016.02.018

Energy metabolism in neuronal/glial induction and in iPSC models of brain disorders

Barbara Mlody
, Carmen Lorenz
, Gizem Inak
, Alessandro Prigione

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

The metabolic switch associated with the reprogramming of somatic cells to pluripotency has received increasing attention in recent years. However, the impact of mitochondrial and metabolic modulation on stem cell differentiation into neuronal/glial cells and related brain disease modeling still remains to be fully addressed. Here, we seek to focus on this aspect by first addressing brain energy metabolism and its inter-cellular metabolic compartmentalization. We then review the findings related to the mitochondrial and metabolic reconfiguration occurring upon neuronal/glial specification from pluripotent stem cells (PSCs). Finally, we provide an update of the PSC-based models of mitochondria-related brain disorders and discuss the challenges and opportunities that may exist on the road to develop a new era of brain disease modeling and therapy.

Original language	English
Pages (from-to)	102-109
Number of pages	8
Journal	Seminars in Cell and Developmental Biology
Volume	52
DOIs	https://doi.org/10.1016/j.semcdb.2016.02.018
State	Published - 1 Apr 2016
Externally published	Yes

Keywords

Glia
IPSCs
Metabolism
Mitochondria
Mitochondrial disorders
Neural progenitors
Neurons
Reprogramming

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10.1016/j.semcdb.2016.02.018

Cite this

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title = "Energy metabolism in neuronal/glial induction and in iPSC models of brain disorders",

abstract = "The metabolic switch associated with the reprogramming of somatic cells to pluripotency has received increasing attention in recent years. However, the impact of mitochondrial and metabolic modulation on stem cell differentiation into neuronal/glial cells and related brain disease modeling still remains to be fully addressed. Here, we seek to focus on this aspect by first addressing brain energy metabolism and its inter-cellular metabolic compartmentalization. We then review the findings related to the mitochondrial and metabolic reconfiguration occurring upon neuronal/glial specification from pluripotent stem cells (PSCs). Finally, we provide an update of the PSC-based models of mitochondria-related brain disorders and discuss the challenges and opportunities that may exist on the road to develop a new era of brain disease modeling and therapy.",

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author = "Barbara Mlody and Carmen Lorenz and Gizem Inak and Alessandro Prigione",

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doi = "10.1016/j.semcdb.2016.02.018",

language = "English",

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TY - JOUR

T1 - Energy metabolism in neuronal/glial induction and in iPSC models of brain disorders

AU - Mlody, Barbara

AU - Lorenz, Carmen

AU - Inak, Gizem

AU - Prigione, Alessandro

PY - 2016/4/1

Y1 - 2016/4/1

N2 - The metabolic switch associated with the reprogramming of somatic cells to pluripotency has received increasing attention in recent years. However, the impact of mitochondrial and metabolic modulation on stem cell differentiation into neuronal/glial cells and related brain disease modeling still remains to be fully addressed. Here, we seek to focus on this aspect by first addressing brain energy metabolism and its inter-cellular metabolic compartmentalization. We then review the findings related to the mitochondrial and metabolic reconfiguration occurring upon neuronal/glial specification from pluripotent stem cells (PSCs). Finally, we provide an update of the PSC-based models of mitochondria-related brain disorders and discuss the challenges and opportunities that may exist on the road to develop a new era of brain disease modeling and therapy.

AB - The metabolic switch associated with the reprogramming of somatic cells to pluripotency has received increasing attention in recent years. However, the impact of mitochondrial and metabolic modulation on stem cell differentiation into neuronal/glial cells and related brain disease modeling still remains to be fully addressed. Here, we seek to focus on this aspect by first addressing brain energy metabolism and its inter-cellular metabolic compartmentalization. We then review the findings related to the mitochondrial and metabolic reconfiguration occurring upon neuronal/glial specification from pluripotent stem cells (PSCs). Finally, we provide an update of the PSC-based models of mitochondria-related brain disorders and discuss the challenges and opportunities that may exist on the road to develop a new era of brain disease modeling and therapy.

KW - Glia

KW - IPSCs

KW - Metabolism

KW - Mitochondria

KW - Mitochondrial disorders

KW - Neural progenitors

KW - Neurons

KW - Reprogramming

UR - https://www.scopus.com/pages/publications/84961197513

U2 - 10.1016/j.semcdb.2016.02.018

DO - 10.1016/j.semcdb.2016.02.018

M3 - Review article

C2 - 26877213

AN - SCOPUS:84961197513

SN - 1084-9521

VL - 52

SP - 102

EP - 109

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

ER -

Energy metabolism in neuronal/glial induction and in iPSC models of brain disorders

Abstract

Keywords

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