Energy metabolism and turnover are increased in mice lacking the cholecystokinin-B receptor

Kyoko Miyasaka; Mineko Ichikawa; Minoru Ohta; Setsuko Kanai; Yuki Yoshida; Masao Masuda; Aki Nagata; Toshimitsu Matsui; Tetsuo Noda; Soichi Takiguchi; Yutaka Takata; Takako Kawanami; Akihiro Funakoshi

doi:10.1093/jn/132.4.739

Energy metabolism and turnover are increased in mice lacking the cholecystokinin-B receptor

Kyoko Miyasaka, Mineko Ichikawa, Minoru Ohta, Setsuko Kanai, Yuki Yoshida, Masao Masuda, Aki Nagata, Toshimitsu Matsui, Tetsuo Noda, Soichi Takiguchi, Yutaka Takata, Takako Kawanami, Akihiro Funakoshi

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Cholecystokinin (CCK) is an important gastrointestinal hormone as well as a neurotransmitter. Two types of CCK receptors, types A and B, have been identified. The CCK-A receptor is involved in satiety, food intake and behavior, whereas the B receptor is involved in anxiety. We recently produced CCK-A, -B and AB receptor knockout mice to study the role of these receptors in energy metabolism. Daily energy intake and expenditure were significantly greater in CCK-BR(-/-) and CCK-AR(-/-) BR(-/-) mice than CCK-AR(-/-) and wild-type [CCK-AR(+/+)BR(+/+)] mice. Relative liver and kidney weights (g/kg body) were significantly greater in CCK-AR(-/-) BR(-/-) mice than in wild-type mice. Energy metabolism and energy turnover were increased in mice with a disruption of the CCK-BR gene, although the underlying mechanism is unknown.

Original language	English
Pages (from-to)	739-741
Number of pages	3
Journal	Journal of Nutrition
Volume	132
Issue number	4
DOIs	https://doi.org/10.1093/jn/132.4.739
State	Published - 2002
Externally published	Yes

Keywords

Cholecystolkinin-receptor
Energy expenditure
Energy intake
Energy metabolism
Knockout mice

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title = "Energy metabolism and turnover are increased in mice lacking the cholecystokinin-B receptor",

abstract = "Cholecystokinin (CCK) is an important gastrointestinal hormone as well as a neurotransmitter. Two types of CCK receptors, types A and B, have been identified. The CCK-A receptor is involved in satiety, food intake and behavior, whereas the B receptor is involved in anxiety. We recently produced CCK-A, -B and AB receptor knockout mice to study the role of these receptors in energy metabolism. Daily energy intake and expenditure were significantly greater in CCK-BR(-/-) and CCK-AR(-/-) BR(-/-) mice than CCK-AR(-/-) and wild-type [CCK-AR(+/+)BR(+/+)] mice. Relative liver and kidney weights (g/kg body) were significantly greater in CCK-AR(-/-) BR(-/-) mice than in wild-type mice. Energy metabolism and energy turnover were increased in mice with a disruption of the CCK-BR gene, although the underlying mechanism is unknown.",

keywords = "Cholecystolkinin-receptor, Energy expenditure, Energy intake, Energy metabolism, Knockout mice",

author = "Kyoko Miyasaka and Mineko Ichikawa and Minoru Ohta and Setsuko Kanai and Yuki Yoshida and Masao Masuda and Aki Nagata and Toshimitsu Matsui and Tetsuo Noda and Soichi Takiguchi and Yutaka Takata and Takako Kawanami and Akihiro Funakoshi",

year = "2002",

doi = "10.1093/jn/132.4.739",

language = "English",

volume = "132",

pages = "739--741",

journal = "Journal of Nutrition",

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TY - JOUR

T1 - Energy metabolism and turnover are increased in mice lacking the cholecystokinin-B receptor

AU - Miyasaka, Kyoko

AU - Ichikawa, Mineko

AU - Ohta, Minoru

AU - Kanai, Setsuko

AU - Yoshida, Yuki

AU - Masuda, Masao

AU - Nagata, Aki

AU - Matsui, Toshimitsu

AU - Noda, Tetsuo

AU - Takiguchi, Soichi

AU - Takata, Yutaka

AU - Kawanami, Takako

AU - Funakoshi, Akihiro

PY - 2002

Y1 - 2002

N2 - Cholecystokinin (CCK) is an important gastrointestinal hormone as well as a neurotransmitter. Two types of CCK receptors, types A and B, have been identified. The CCK-A receptor is involved in satiety, food intake and behavior, whereas the B receptor is involved in anxiety. We recently produced CCK-A, -B and AB receptor knockout mice to study the role of these receptors in energy metabolism. Daily energy intake and expenditure were significantly greater in CCK-BR(-/-) and CCK-AR(-/-) BR(-/-) mice than CCK-AR(-/-) and wild-type [CCK-AR(+/+)BR(+/+)] mice. Relative liver and kidney weights (g/kg body) were significantly greater in CCK-AR(-/-) BR(-/-) mice than in wild-type mice. Energy metabolism and energy turnover were increased in mice with a disruption of the CCK-BR gene, although the underlying mechanism is unknown.

AB - Cholecystokinin (CCK) is an important gastrointestinal hormone as well as a neurotransmitter. Two types of CCK receptors, types A and B, have been identified. The CCK-A receptor is involved in satiety, food intake and behavior, whereas the B receptor is involved in anxiety. We recently produced CCK-A, -B and AB receptor knockout mice to study the role of these receptors in energy metabolism. Daily energy intake and expenditure were significantly greater in CCK-BR(-/-) and CCK-AR(-/-) BR(-/-) mice than CCK-AR(-/-) and wild-type [CCK-AR(+/+)BR(+/+)] mice. Relative liver and kidney weights (g/kg body) were significantly greater in CCK-AR(-/-) BR(-/-) mice than in wild-type mice. Energy metabolism and energy turnover were increased in mice with a disruption of the CCK-BR gene, although the underlying mechanism is unknown.

KW - Cholecystolkinin-receptor

KW - Energy expenditure

KW - Energy intake

KW - Energy metabolism

KW - Knockout mice

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U2 - 10.1093/jn/132.4.739

DO - 10.1093/jn/132.4.739

M3 - Article

C2 - 11925470

AN - SCOPUS:0036221330

SN - 0022-3166

VL - 132

SP - 739

EP - 741

JO - Journal of Nutrition

JF - Journal of Nutrition

IS - 4

ER -

Energy metabolism and turnover are increased in mice lacking the cholecystokinin-B receptor

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Keywords

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