TY - JOUR
T1 - Endovascular treatment or neurosurgical clipping of ruptured intracranial aneurysms
T2 - Effect on angiographic vasospasm, delayed ischemic neurological deficit, cerebral infarction, and clinical outcome
AU - Dumont, Aaron S.
AU - Crowley, R. Webster
AU - Monteith, Stephen J.
AU - Ilodigwe, Don
AU - Kassell, Neal F.
AU - Mayer, Stephan
AU - Ruefenacht, Daniel
AU - Weidauer, Stephan
AU - Pasqualin, Alberto
AU - MacDonald, R. Loch
PY - 2010/11
Y1 - 2010/11
N2 - Background and Purpose: The effects of aneurysm treatment modality (clipping or coiling) on the incidence of cerebral vasospasm and infarction after subarachnoid hemorrhage have not been clearly defined. We hypothesized that there may be a difference in angiographic and clinical vasospasm, cerebral infarction, and clinical outcome between patients undergoing clipping compared to coiling. Methods: A retrospective, exploratory analysis of 413 patients randomized into the CONSCIOUS-1 trial was conducted. Patients underwent baseline and follow-up catheter angiography and computed tomography, as well as clinical assessments. Radiology end points were adjudicated by central blinded review, and angiographic vasospasm was quantified by measurements of arterial diameters on catheter angiography. The effect of method of aneurysm treatment (clipping [n=199] or coiling [n=214]) on angiographic vasospasm, delayed ischemic neurological deficit, cerebral infarction, and clinical outcome was analyzed using univariate and multivariate logistic regression. Propensity matching was used to adjust for differences in baseline risk factors between clipped and coiled patients. Results: In all patients and the propensity-matched subset, aneurysm coiling was associated with a significantly reduced risk of angiographic vasospasm and delayed ischemic neurological deficit compared to clipping. Cerebral infarction and clinical outcome were not associated with clipping or coiling. Conclusions: In this exploratory analysis, aneurysm coiling was associated with less angiographic vasospasm and delayed ischemic neurological deficit than surgical clipping, whereas no effect on cerebral infarction or clinical outcome was observed. Whether this is attributable to differences in baseline risk factors between clipped and coiled patients or a true difference cannot be proven here.
AB - Background and Purpose: The effects of aneurysm treatment modality (clipping or coiling) on the incidence of cerebral vasospasm and infarction after subarachnoid hemorrhage have not been clearly defined. We hypothesized that there may be a difference in angiographic and clinical vasospasm, cerebral infarction, and clinical outcome between patients undergoing clipping compared to coiling. Methods: A retrospective, exploratory analysis of 413 patients randomized into the CONSCIOUS-1 trial was conducted. Patients underwent baseline and follow-up catheter angiography and computed tomography, as well as clinical assessments. Radiology end points were adjudicated by central blinded review, and angiographic vasospasm was quantified by measurements of arterial diameters on catheter angiography. The effect of method of aneurysm treatment (clipping [n=199] or coiling [n=214]) on angiographic vasospasm, delayed ischemic neurological deficit, cerebral infarction, and clinical outcome was analyzed using univariate and multivariate logistic regression. Propensity matching was used to adjust for differences in baseline risk factors between clipped and coiled patients. Results: In all patients and the propensity-matched subset, aneurysm coiling was associated with a significantly reduced risk of angiographic vasospasm and delayed ischemic neurological deficit compared to clipping. Cerebral infarction and clinical outcome were not associated with clipping or coiling. Conclusions: In this exploratory analysis, aneurysm coiling was associated with less angiographic vasospasm and delayed ischemic neurological deficit than surgical clipping, whereas no effect on cerebral infarction or clinical outcome was observed. Whether this is attributable to differences in baseline risk factors between clipped and coiled patients or a true difference cannot be proven here.
KW - cerebral vasospasm
KW - clazosentan
KW - endothelin-1
KW - intracranial aneurysm
KW - subarachnoid hemorrhage
UR - https://www.scopus.com/pages/publications/78149362152
U2 - 10.1161/STROKEAHA.110.579383
DO - 10.1161/STROKEAHA.110.579383
M3 - Article
C2 - 20813994
AN - SCOPUS:78149362152
SN - 0039-2499
VL - 41
SP - 2519
EP - 2524
JO - Stroke
JF - Stroke
IS - 11
ER -