Endothelium Dependent Constriction by Angiotensin II Demonstrated in Vivo in Mouse Brain Arterioles

William I. Rosenblum; Guy H. Nelson; Takao Shimizu

doi:10.3109/10623329509024660

Endothelium Dependent Constriction by Angiotensin II Demonstrated in Vivo in Mouse Brain Arterioles

William I. Rosenblum, Guy H. Nelson, Takao Shimizu

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Pial arterioles 30-50 μ m wide were monitored in vivo using a television - microscopy -image splitting technique. Topical angiotensin II constricted the vessels in dose dependent manner. Selective endothelial injury with a helium neon laser/Evans blue technique abolished modest responses to All and greatly reduced larger responses. Thus, All produces endothelium dependent constriction of arterioles in vivo in this portion of the brains micro vascular tree.

Original language	English
Pages (from-to)	63-66
Number of pages	4
Journal	Endothelium
Volume	3
Issue number	1
DOIs	https://doi.org/10.3109/10623329509024660
State	Published - 1 Jan 1995
Externally published	Yes

Keywords

angiotensin
cerebral microcirculation
endothelial injury
endothelium dependent constriction

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10.3109/10623329509024660

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title = "Endothelium Dependent Constriction by Angiotensin II Demonstrated in Vivo in Mouse Brain Arterioles",

abstract = "Pial arterioles 30-50 μ m wide were monitored in vivo using a television - microscopy -image splitting technique. Topical angiotensin II constricted the vessels in dose dependent manner. Selective endothelial injury with a helium neon laser/Evans blue technique abolished modest responses to All and greatly reduced larger responses. Thus, All produces endothelium dependent constriction of arterioles in vivo in this portion of the brains micro vascular tree.",

keywords = "angiotensin, cerebral microcirculation, endothelial injury, endothelium dependent constriction",

author = "Rosenblum, {William I.} and Nelson, {Guy H.} and Takao Shimizu",

note = "Funding Information: Reprint requests and correspondence to Dr. Rosenblum, Box 980017, MCV Station, Richmond, Virginia 23298-0017. Tel: 804 828-9735 Dr. Rosenblum. Fax: 804 828-3299 Dr. Rosenblum. **Supported by grants HU5935; and HL45617 from the National Heart Lung Institute.",

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doi = "10.3109/10623329509024660",

language = "English",

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AU - Rosenblum, William I.

AU - Nelson, Guy H.

AU - Shimizu, Takao

N1 - Funding Information: Reprint requests and correspondence to Dr. Rosenblum, Box 980017, MCV Station, Richmond, Virginia 23298-0017. Tel: 804 828-9735 Dr. Rosenblum. Fax: 804 828-3299 Dr. Rosenblum. **Supported by grants HU5935; and HL45617 from the National Heart Lung Institute.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Pial arterioles 30-50 μ m wide were monitored in vivo using a television - microscopy -image splitting technique. Topical angiotensin II constricted the vessels in dose dependent manner. Selective endothelial injury with a helium neon laser/Evans blue technique abolished modest responses to All and greatly reduced larger responses. Thus, All produces endothelium dependent constriction of arterioles in vivo in this portion of the brains micro vascular tree.

AB - Pial arterioles 30-50 μ m wide were monitored in vivo using a television - microscopy -image splitting technique. Topical angiotensin II constricted the vessels in dose dependent manner. Selective endothelial injury with a helium neon laser/Evans blue technique abolished modest responses to All and greatly reduced larger responses. Thus, All produces endothelium dependent constriction of arterioles in vivo in this portion of the brains micro vascular tree.

KW - angiotensin

KW - cerebral microcirculation

KW - endothelial injury

KW - endothelium dependent constriction

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EP - 66

JO - Endothelium

JF - Endothelium

IS - 1

ER -

Endothelium Dependent Constriction by Angiotensin II Demonstrated in Vivo in Mouse Brain Arterioles

Abstract

Keywords

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