Endothelial growth factor receptor inhibitors in recurrent metastatic cancer of the head and neck

Krzysztof Misiukiewicz, Rajan P. Dang, Michael Parides, Nadia Camille, Helen Uczkowski, Nicholas J. Sarlis, Marshall Posner

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Targeted therapy has become an important new class of therapeutic agents used in squamous cell carcinoma of the head and neck (SCCHN). Among them epidermal growth factor receptor (EGFR) inhibitors have been studied the most. Today, two classes of EGFR inhibitors are routinely used in the clinic; anti-EGFR monoclonal antibodies and small-molecule inhibitors of the EGFR tyrosine kinase activity. These agents have been used clinically in the recurrent metastatic (R/M) settings but only cetuximab has reached a regulatory approval. Current research is focused on innovative compound design, predictive biomarker discovery, and combination strategies in order to overcome resistance. Efforts should also be focused on endpoints other than overall survival, which is the current gold standard, such as surrogate endpoints. This article summarizes the clinical evidence of the anticancer activity of EGFR inhibitors in patients with R/M SCCHN, and analyzes the current, controversial clinical issues with respect to their interpretation.

Original languageEnglish
Pages (from-to)E2221-E2228
JournalHead and Neck
StatePublished - 1 Apr 2016


  • cetuximab
  • endothelial growth factor receptor (EGFR)
  • head and neck cancer
  • panitumumab
  • squamous cell carcinoma (SCC)


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