Endoscopic ultrasound delivery of an antitumor agent to treat a case of pancreatic cancer

Kenneth J. Chang, John G. Lee, Randall F. Holcombe, Jeffrey Kuo, Raman Muthusamy, Mark L. Wu, H. H. Chao

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


Background: A 72-year-old white male presented to a University Digestive Disease Center with epigastric pain and weight loss. A CT scan suggested that the patient had a mass in his pancreas and he was referred for further diagnostic work-up, staging and treatment. Investigations: Endoscopic ultrasound (EUS), EUS-guided fine-needle aspiration. Diagnosis: Locally advanced, unresectable adenocarcinoma ofthe pancreas. Management Opioid analgesics and EUS-guided celiac neurolysis (transgastric injection of bupivacaine and alcohol on both sides of the celiac artery) for pain relief. Five once-weekly intratumoral injections of TNFerade™ (GenVec, Inc., Gaithersburg, MD) by EUS-guided fine needle injection, in combination with chemoradiation (5 FU/XRT), as part of a multicenter clinical trial. Repeat fine-needle aspiration followed by surgical resection of the tumor.

Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalNature Clinical Practice Gastroenterology and Hepatology
Issue number2
StatePublished - Feb 2008
Externally publishedYes


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