Endometrial carcinoma and oral contraceptive agents

Carmel J. Cohen, Gunter Deppe

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Six patients who took oral contraceptive agents for 5 to 18 years developed endometrial neoplasia. Endometrial adenocarcinoma occurred in 4 of these patients and severe adenomatous hyperplasia occured in 2. Five of the 6 patients took sequential agents; 1 patient used a combined agent. An additional patient who took Premarin and Provera sequentially developed adenocarcinoma of the endometrium. Eighteen cases of endometrial adenocarcinoma and 7 cases of adenomatous hyperplasia in patients with long-term sequential oral contraceptive use have previously been reported by others. Progestogens may not be completely protective against the endometrial cancer-causing potential of the estrogens, especially in the sequential regimens.

Original languageEnglish
Pages (from-to)390-392
Number of pages3
JournalObstetrics and Gynecology
Issue number4
StatePublished - Apr 1977


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