Endogenous serum levels of thrombopoietic cytokines in healthy whole- blood and platelet donors: Implications for plateletpheresis

F. Tacke, P. Schöffski, C. Trautwein, M. U. Martin, W. Stangel, E. Seifried, M. P. Manns, A. Ganser, D. Petersen

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Serum concentrations of the thrombopoiesis-enhancing cytokines thrombopoietin (TPO), erythropoietin (EPO), interleukin (IL)-6 and IL-11 were determined in 119 healthy whole-blood (WBD) and 101 platelet donors (PD) prior to donation. The 90% TPO reference interval in WBD of 64-867pg/ml (median 163, 100% range 45-7572) was significantly higher than in PD of 56- 524 (median 122, range 44-801, P=0.004), whereas their platelet counts were lower (P<0.001). EPO levels were not different (WBD 7.7 ± 3.8, PD 8.0 ± 4.9 IU/l), IL-6 and IL-11 were below the detection limit in ≥90% of cases (IL-6 < 3.2 pg/ml, IL-11 < 31.2 pg/ml). None of the cytokines correlated with platelet counts, other blood parameters, or in the PD group with the frequency of platelet donations within the last 6 months. We conclude that plateletpheresis does not lead to a lasting increase of thrombopoietic cytokines and provide reference data for potential platelet mobilization strategies with recombinant growth factors.

Original languageEnglish
Pages (from-to)511-513
Number of pages3
JournalBritish Journal of Haematology
Volume105
Issue number2
DOIs
StatePublished - 1999
Externally publishedYes

Keywords

  • Erythropoietin
  • Interleukin- 6
  • Interleukin-11
  • Plateletpheresis
  • Thrombopoietin

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