Endogenous opiates and behavior: 2017

Richard J. Bodnar

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

This paper is the fortieth consecutive installment of the annual anthological review of research concerning the endogenous opioid system, summarizing articles published during 2017 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides and receptors as well as effects of opioid/opiate agonists and antagonists. The review is subdivided into the following specific topics: molecular-biochemical effects and neurochemical localization studies of endogenous opioids and their receptors (1), the roles of these opioid peptides and receptors in pain and analgesia in animals (2) and humans (3), opioid-sensitive and opioid-insensitive effects of nonopioid analgesics (4), opioid peptide and receptor involvement in tolerance and dependence (5), stress and social status (6), learning and memory (7), eating and drinking (8), drug abuse and alcohol (9), sexual activity and hormones, pregnancy, development and endocrinology (10), mental illness and mood (11), seizures and neurologic disorders (12), electrical-related activity and neurophysiology (13), general activity and locomotion (14), gastrointestinal, renal and hepatic functions (15), cardiovascular responses (16), respiration and thermoregulation (17), and immunological responses (18).

Original languageEnglish
Article number170223
JournalPeptides
Volume124
DOIs
StatePublished - Feb 2020
Externally publishedYes

Keywords

  • Delta opioid receptor
  • Dynorphins
  • Endomorphins
  • Endorphins
  • Enkephalins
  • Kappa opioid receptor
  • Mu opioid receptor
  • Nociception
  • Orphan opioid receptor
  • Tolerance and dependence

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