Endogenous C type viruses of BALB/c cells: Frequencies of spontaneous and chemical induction

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Abstract

A sensitive biological assay has been developed for studying the frequency of virus induction from mouse cells containing poorly infectious endogenous C type viruses. A low spontaneous frequency of virus activation of one but not a second endogenous virus of BALB/c cells has been demonstrated. The resistance of BALB/c cells to superinfection by the more inducible virus appears to be absolute, whereas resistance to the other virus is only relative. Evidence indicates that the BALB/c cell exerts differential effects at two levels of regulation on the expression of its biologically distinguishable endogenous C type viruses.

Original languageEnglish
Pages (from-to)181-185
Number of pages5
JournalJournal of Virology
Volume13
Issue number1
DOIs
StatePublished - 1974
Externally publishedYes

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