The endogenous formation of n‑propanol under the influence of ethanol has been the subject of discussion for some years. Especially the location of the formation of endogenous n‑propanol is unknown. Therefore, an experiment with intravenous ethanol administration to bypass the intestinal tract was performed with one test person. The intestine or the liver is discussed to be the location of endogenous n‑propanol formation. The results of the intravenous administration of ethanol look similar to the results from previous drinking experiments. With rising blood alcohol concentration (BAC) a rising n‑propanol concentration could also be observed. In the first blood sample (zero sample) no n‑propanol was detectable. The results show that the intestine is probably not the location of the endogenous n‑propanol formation. For the elucidation of the location and mechanism of endogenous n‑propanol formation further experiments are necessary.
|Translated title of the contribution||Endogenous formation of n-propanol: Analysis in the human organism under the influence of ethanol|
|Number of pages||5|
|State||Published - Oct 2022|
- Hip flask defence
- Intravenous ethanol administration
- Microbiotic formation
- Physiological concentration