TY - JOUR
T1 - Endocytosis and signalling
T2 - A meeting with mathematics
AU - Birtwistle, Marc R.
AU - Kholodenko, Boris N.
N1 - Funding Information:
BNK is a SFI Stokes Professor in Systems Biology, and is supported by a SFI Centre for Science Engineering and Technology grant and NIH grants GM059570 and R33HL088283. MRB is supported by a Marie Curie International Incoming Fellowship.
PY - 2009/8
Y1 - 2009/8
N2 - Although endocytosis has traditionally been understood as a signal attenuation mechanism, an emerging view considers endocytosis as an integral part of signal propagation and processing. On the short time scale, trafficking of endocytic vesicles contributes to signal propagation from the surface to distant targets, with bi-directional communication between signalling and trafficking. Mathematical modelling helps combine the mechanistic, molecular knowledge with rigorous analysis of the complex output dynamics of endocytosis in time and space. Simulations reveal novel roles for endocytosis, including the control of cell polarity, enhancing the spatial signal propagation, and controlling the signal magnitudes, kinetics, and synchronization with stimulus dynamics.
AB - Although endocytosis has traditionally been understood as a signal attenuation mechanism, an emerging view considers endocytosis as an integral part of signal propagation and processing. On the short time scale, trafficking of endocytic vesicles contributes to signal propagation from the surface to distant targets, with bi-directional communication between signalling and trafficking. Mathematical modelling helps combine the mechanistic, molecular knowledge with rigorous analysis of the complex output dynamics of endocytosis in time and space. Simulations reveal novel roles for endocytosis, including the control of cell polarity, enhancing the spatial signal propagation, and controlling the signal magnitudes, kinetics, and synchronization with stimulus dynamics.
KW - Endocytosis
KW - Mathematical modelling
KW - Signal transduction
KW - Spatial gradients
KW - Spatiotemporal dynamics
UR - http://www.scopus.com/inward/record.url?scp=67949101916&partnerID=8YFLogxK
U2 - 10.1016/j.molonc.2009.05.009
DO - 10.1016/j.molonc.2009.05.009
M3 - Review article
C2 - 19596615
AN - SCOPUS:67949101916
SN - 1574-7891
VL - 3
SP - 308
EP - 320
JO - Molecular Oncology
JF - Molecular Oncology
IS - 4
ER -