Abstract

Endocrine disruptive chemicals (EDC) are known to alter thyroid function and have been associated with increased risk of certain cancers. The present study aims to provide a comprehensive overview of available studies on the association between EDC exposure and thyroid cancer. Relevant studies were identified via a literature search in the National Library of Medicine and National Institutes of Health PubMed as well as a review of reference lists of all retrieved articles and of previously published relevant reviews. Overall, the current literature suggests that exposure to certain congeners of flame retardants, polychlorinated biphenyls (PCBs), and phthalates as well as certain pesticides may potentially be associated with an increased risk of thyroid cancer. However, future research is urgently needed to evaluate the different EDCs and their potential carcinogenic effect on the thyroid gland in humans as most EDCs have been studied sporadically and results are not consistent.

Original languageEnglish
Article number14
Pages (from-to)1-26
Number of pages26
JournalToxics
Volume9
Issue number1
DOIs
StatePublished - Dec 2021

Keywords

  • Bisphenol A
  • Endocrine disruptive chemicals
  • Flame retardants
  • Perfluoroalkyl substances
  • Pesticides
  • Phthalates
  • Polychlorinated biphenyls
  • Thyroid cancer

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