TY - JOUR
T1 - Endocrine diagnosis of pituitary tumor in galactorrhea syndromes
AU - Kase, Nathan
AU - Andriole, Joseph P.
AU - Sobrinho, Luis
N1 - Funding Information:
These studies were conducted in the Yale University School of Medicine Clinical Research Center under Grant No. RR 00125 (9070-41-51571). Presented by invitation at the Ninety-fifth Annual Meeting of the American Gynecological Society, Hot Springs, Virginia, May 18-20, 1972.
PY - 1972/10/1
Y1 - 1972/10/1
N2 - Endocrine aspects of 17 patients with inappropriate galactorrhea were evaluated. Six of the patients had radiographic evidence of pituitary tumor, and in two, on whom operation was performed, chromophobe adenoma was found. All patients suspected of having tumors had normal thyroid and adrenal function, and only one did not respond fully to metyrapone. Hypothyroidism and Cushing's syndrome were presumed causes of galactorrhea found among the "nontumor" group. All the "tumor" patients and three of the "nontumor" group had marginal or subnormal growth hormone responses to arginine. Serum luteinizing hormone (LH) levels displayed marked variability in both categories of patients. A sequence of gonadotropin loss secondary to tumor compression is suggested in which follicle-stimulating hormone is diminished prior to LH. The future usefulness of exogenous testing with l-dopa and synthetic LRF in galactorrheic syndromes is cited.
AB - Endocrine aspects of 17 patients with inappropriate galactorrhea were evaluated. Six of the patients had radiographic evidence of pituitary tumor, and in two, on whom operation was performed, chromophobe adenoma was found. All patients suspected of having tumors had normal thyroid and adrenal function, and only one did not respond fully to metyrapone. Hypothyroidism and Cushing's syndrome were presumed causes of galactorrhea found among the "nontumor" group. All the "tumor" patients and three of the "nontumor" group had marginal or subnormal growth hormone responses to arginine. Serum luteinizing hormone (LH) levels displayed marked variability in both categories of patients. A sequence of gonadotropin loss secondary to tumor compression is suggested in which follicle-stimulating hormone is diminished prior to LH. The future usefulness of exogenous testing with l-dopa and synthetic LRF in galactorrheic syndromes is cited.
UR - http://www.scopus.com/inward/record.url?scp=0015407292&partnerID=8YFLogxK
U2 - 10.1016/0002-9378(72)90609-6
DO - 10.1016/0002-9378(72)90609-6
M3 - Article
C2 - 4118037
AN - SCOPUS:0015407292
SN - 0002-9378
VL - 114
SP - 321
EP - 328
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 3
ER -