Post-traumatic stress disorder (PTSD) is a serious, multisystem disorder with multiple medical comorbidities. This article reviews the current literature on the endocrine aspects of PTSD, specifically hypothalamic-pituitary-adrenal axis alterations indicative of low cortisol and increased glucocorticoid sensitivity, and the proposed mechanisms whereby these alterations increase risk or reflect pathophysiology. Discussion includes novel treatment innovations and directions for future research.
|Number of pages||11|
|Journal||Endocrinology and Metabolism Clinics of North America|
|State||Published - Sep 2013|
- Hypothalamic-pituitary-adrenal axis
- Post-traumatic stress disorder