Endocrine Aspects of Post-traumatic Stress Disorder and Implications for Diagnosis and Treatment

Nikolaos P. Daskalakis; Amy Lehrner; Rachel Yehuda

doi:10.1016/j.ecl.2013.05.004

Endocrine Aspects of Post-traumatic Stress Disorder and Implications for Diagnosis and Treatment

Nikolaos P. Daskalakis, Amy Lehrner, Rachel Yehuda

Research output: Contribution to journal › Review article › peer-review

168 Scopus citations

Abstract

Post-traumatic stress disorder (PTSD) is a serious, multisystem disorder with multiple medical comorbidities. This article reviews the current literature on the endocrine aspects of PTSD, specifically hypothalamic-pituitary-adrenal axis alterations indicative of low cortisol and increased glucocorticoid sensitivity, and the proposed mechanisms whereby these alterations increase risk or reflect pathophysiology. Discussion includes novel treatment innovations and directions for future research.

Original language	English
Pages (from-to)	503-513
Number of pages	11
Journal	Endocrinology and Metabolism Clinics of North America
Volume	42
Issue number	3
DOIs	https://doi.org/10.1016/j.ecl.2013.05.004
State	Published - Sep 2013

Keywords

Cortisol
Hypothalamic-pituitary-adrenal axis
Post-traumatic stress disorder
Stress
Sympathetic

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10.1016/j.ecl.2013.05.004

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Endocrine Aspects of Post-traumatic Stress Disorder and Implications for Diagnosis and Treatment

Abstract

Keywords

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