Endocervical glandular involvement is associated with high-grade SIL

Chandandeep S. Nagi; Peter W. Schlosshauer

doi:10.1016/j.ygyno.2005.12.029

Endocervical glandular involvement is associated with high-grade SIL

Chandandeep S. Nagi, Peter W. Schlosshauer

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Objective.: To examine whether endocervical glandular involvement (EGI) by squamous intraepithelial lesions (SIL) is associated with the grade of the squamous lesion and to assess the usefulness of such association for diagnostic purposes. Methods.: Histologic sections from two hundred successive cases of cervical SIL were reviewed retrospectively from the archives of the Department of Pathology of a tertiary care medical center. Results.: Nine of 93 (9.7%) low-grade lesions and 41 of 107 (38.3%) high-grade lesions showed glandular involvement (P = 0.001, Chi-squared test). The relative risk of having EGI in high-grade lesions as compared to low-grade lesions was 3.95. Conclusion.: EGI is seen approximately four times more frequently in high-grade SIL than in low-grade SIL. Therefore, in cases that are difficult to grade, the presence of EGI is in favor of the lesion being a high-grade SIL.

Original language	English
Pages (from-to)	240-243
Number of pages	4
Journal	Gynecologic Oncology
Volume	102
Issue number	2
DOIs	https://doi.org/10.1016/j.ygyno.2005.12.029
State	Published - Aug 2006

Keywords

CIN
Cervical dysplasia
Endocervical glands
Grading
SIL

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10.1016/j.ygyno.2005.12.029

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@article{17eb9ce4d10b4036b27133a139e6b4f1,

title = "Endocervical glandular involvement is associated with high-grade SIL",

abstract = "Objective.: To examine whether endocervical glandular involvement (EGI) by squamous intraepithelial lesions (SIL) is associated with the grade of the squamous lesion and to assess the usefulness of such association for diagnostic purposes. Methods.: Histologic sections from two hundred successive cases of cervical SIL were reviewed retrospectively from the archives of the Department of Pathology of a tertiary care medical center. Results.: Nine of 93 (9.7%) low-grade lesions and 41 of 107 (38.3%) high-grade lesions showed glandular involvement (P = 0.001, Chi-squared test). The relative risk of having EGI in high-grade lesions as compared to low-grade lesions was 3.95. Conclusion.: EGI is seen approximately four times more frequently in high-grade SIL than in low-grade SIL. Therefore, in cases that are difficult to grade, the presence of EGI is in favor of the lesion being a high-grade SIL.",

keywords = "CIN, Cervical dysplasia, Endocervical glands, Grading, SIL",

author = "Nagi, {Chandandeep S.} and Schlosshauer, {Peter W.}",

note = "Funding Information: This study was supported by the Department of Pathology, The Mount Sinai School of Medicine.",

year = "2006",

month = aug,

doi = "10.1016/j.ygyno.2005.12.029",

language = "English",

volume = "102",

pages = "240--243",

journal = "Gynecologic Oncology",

issn = "0090-8258",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - Endocervical glandular involvement is associated with high-grade SIL

AU - Nagi, Chandandeep S.

AU - Schlosshauer, Peter W.

N1 - Funding Information: This study was supported by the Department of Pathology, The Mount Sinai School of Medicine.

PY - 2006/8

Y1 - 2006/8

N2 - Objective.: To examine whether endocervical glandular involvement (EGI) by squamous intraepithelial lesions (SIL) is associated with the grade of the squamous lesion and to assess the usefulness of such association for diagnostic purposes. Methods.: Histologic sections from two hundred successive cases of cervical SIL were reviewed retrospectively from the archives of the Department of Pathology of a tertiary care medical center. Results.: Nine of 93 (9.7%) low-grade lesions and 41 of 107 (38.3%) high-grade lesions showed glandular involvement (P = 0.001, Chi-squared test). The relative risk of having EGI in high-grade lesions as compared to low-grade lesions was 3.95. Conclusion.: EGI is seen approximately four times more frequently in high-grade SIL than in low-grade SIL. Therefore, in cases that are difficult to grade, the presence of EGI is in favor of the lesion being a high-grade SIL.

AB - Objective.: To examine whether endocervical glandular involvement (EGI) by squamous intraepithelial lesions (SIL) is associated with the grade of the squamous lesion and to assess the usefulness of such association for diagnostic purposes. Methods.: Histologic sections from two hundred successive cases of cervical SIL were reviewed retrospectively from the archives of the Department of Pathology of a tertiary care medical center. Results.: Nine of 93 (9.7%) low-grade lesions and 41 of 107 (38.3%) high-grade lesions showed glandular involvement (P = 0.001, Chi-squared test). The relative risk of having EGI in high-grade lesions as compared to low-grade lesions was 3.95. Conclusion.: EGI is seen approximately four times more frequently in high-grade SIL than in low-grade SIL. Therefore, in cases that are difficult to grade, the presence of EGI is in favor of the lesion being a high-grade SIL.

KW - CIN

KW - Cervical dysplasia

KW - Endocervical glands

KW - Grading

KW - SIL

UR - http://www.scopus.com/inward/record.url?scp=33745912543&partnerID=8YFLogxK

U2 - 10.1016/j.ygyno.2005.12.029

DO - 10.1016/j.ygyno.2005.12.029

M3 - Article

C2 - 16472847

AN - SCOPUS:33745912543

SN - 0090-8258

VL - 102

SP - 240

EP - 243

JO - Gynecologic Oncology

JF - Gynecologic Oncology

IS - 2

ER -

Endocervical glandular involvement is associated with high-grade SIL

Abstract

Keywords

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