Encounter and React: Computer-Guided Design of Covalent Inhibitors

Peter Man Un Ung; Robert J. DeVita; Avner Schlessinger

doi:10.1016/j.chembiol.2018.12.009

Encounter and React: Computer-Guided Design of Covalent Inhibitors

Peter Man Un Ung, Robert J. DeVita, Avner Schlessinger

Research output: Contribution to journal › Short survey › peer-review

2 Scopus citations

Abstract

Covalent inhibitors can obtain optimal selectivity and extended residence time. In this issue of Cell Chemical Biology, Shraga et al. (2019) take a comprehensive computational and experimental approach to modulate the JNK-Jun pathway through design of MKK7 covalent inhibitors. This study highlights a promising and emerging strategy for therapeutic discovery.

Original language	English
Pages (from-to)	6-8
Number of pages	3
Journal	Cell Chemical Biology
Volume	26
Issue number	1
DOIs	https://doi.org/10.1016/j.chembiol.2018.12.009
State	Published - 17 Jan 2019

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title = "Encounter and React: Computer-Guided Design of Covalent Inhibitors",

abstract = "Covalent inhibitors can obtain optimal selectivity and extended residence time. In this issue of Cell Chemical Biology, Shraga et al. (2019) take a comprehensive computational and experimental approach to modulate the JNK-Jun pathway through design of MKK7 covalent inhibitors. This study highlights a promising and emerging strategy for therapeutic discovery.",

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AU - DeVita, Robert J.

AU - Schlessinger, Avner

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AB - Covalent inhibitors can obtain optimal selectivity and extended residence time. In this issue of Cell Chemical Biology, Shraga et al. (2019) take a comprehensive computational and experimental approach to modulate the JNK-Jun pathway through design of MKK7 covalent inhibitors. This study highlights a promising and emerging strategy for therapeutic discovery.

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DO - 10.1016/j.chembiol.2018.12.009

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JO - Cell Chemical Biology

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Encounter and React: Computer-Guided Design of Covalent Inhibitors

Abstract

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