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Covalent inhibitors can obtain optimal selectivity and extended residence time. In this issue of Cell Chemical Biology, Shraga et al. (2019) take a comprehensive computational and experimental approach to modulate the JNK-Jun pathway through design of MKK7 covalent inhibitors. This study highlights a promising and emerging strategy for therapeutic discovery.

Original languageEnglish
Pages (from-to)6-8
Number of pages3
JournalCell Chemical Biology
Issue number1
StatePublished - 17 Jan 2019


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