Abstract
When toxicity data are not available for a chemical mixture of concern, U.S. Environmental Protection Agency (EPA) guidelines allow risk assessment to be based on data for a surrogate mixture considered "sufficiently similar" in terms of chemical composition and component proportions. As a supplementary approach, using statistical equivalence testing logic and mixed model theory we have developed methodology to define sufficient similarity in dose-response for mixtures of many chemicals containing the same components with different ratios. Dose-response data from a mixture of 11 xenoestrogens and the endogenous hormone, 17β-estradiol are used to illustrate the method.
Original language | English |
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Pages (from-to) | 313-333 |
Number of pages | 21 |
Journal | Journal of Agricultural, Biological, and Environmental Statistics |
Volume | 13 |
Issue number | 3 |
DOIs | |
State | Published - Sep 2008 |
Externally published | Yes |
Keywords
- Equivalence testing
- Mixed models
- Nonlinear models
- Random coefficient