TY - JOUR
T1 - Emigration of monocyte-derived cells from atherosclerotic lesions characterizes regressive, but not progressive, plaques
AU - Llodrá, Jaime
AU - Angeli, Véronique
AU - Liu, Jianhua
AU - Trogan, Eugene
AU - Fisher, Edward A.
AU - Rendolph, Gwendalyn J.
PY - 2004/8/10
Y1 - 2004/8/10
N2 - Some monocytes normally take up residence in tissues as sessile macrophages, but others differentiate into migratory cells resembling dendritic cells that emigrate to lymph nodes. In an in vitro model of a vessel wall, lipid mediators lysophosphatidic acid and platelet-activating factor, whose signals are implicated in promoting atherosclerosis, blocked conversion of monocytes into migratory cells and favored their retention in the subendothelium. In vivo studies revealed trafficking of monocyte-derived cells from atherosclerotic plaques during lesion regression, but little emigration was detected from progressive plaques. Thus, progression of atherosclerotic plaques may result not only from robust monocyte recruitment into arterial walls but also from reduced emigration of these cells from lesions.
AB - Some monocytes normally take up residence in tissues as sessile macrophages, but others differentiate into migratory cells resembling dendritic cells that emigrate to lymph nodes. In an in vitro model of a vessel wall, lipid mediators lysophosphatidic acid and platelet-activating factor, whose signals are implicated in promoting atherosclerosis, blocked conversion of monocytes into migratory cells and favored their retention in the subendothelium. In vivo studies revealed trafficking of monocyte-derived cells from atherosclerotic plaques during lesion regression, but little emigration was detected from progressive plaques. Thus, progression of atherosclerotic plaques may result not only from robust monocyte recruitment into arterial walls but also from reduced emigration of these cells from lesions.
UR - http://www.scopus.com/inward/record.url?scp=4143092691&partnerID=8YFLogxK
U2 - 10.1073/pnas.0403259101
DO - 10.1073/pnas.0403259101
M3 - Article
C2 - 15280540
AN - SCOPUS:4143092691
SN - 0027-8424
VL - 101
SP - 11779
EP - 11784
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 32
ER -