Emerging roles of E3 ubiquitin ligases in autophagy

Ersheng Kuang, Jianfei Qi, Ze'ev Ronai

Research output: Contribution to journalReview articlepeer-review

93 Scopus citations

Abstract

Autophagy is an evolutionarily conserved intracellular catabolic process that delivers cytoplasmic components to lysosomes for degradation and recycling. Although originally considered to be a non-selective pathway, it is now recognized that autophagy is involved in selective processes, including the turnover of organelles, removal of protein aggregates, and elimination of intracellular pathogens. This specificity implies that cargo recognition and processing by the autophagy machinery are tightly regulated processes. In support of this, various forms of post-translational modification have been implicated in the regulation of autophagy, one of which is the ubiquitin-proteasome system. Here we review current understanding of the role of ubiquitylation in the control of autophagy.

Original languageEnglish
Pages (from-to)453-460
Number of pages8
JournalTrends in Biochemical Sciences
Volume38
Issue number9
DOIs
StatePublished - Sep 2013
Externally publishedYes

Keywords

  • Autophagy
  • Parkin
  • Proteasome
  • RNF5
  • Ubiquitin ligase

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