TY - JOUR
T1 - Emerging concepts in the epidemiology, pathophysiology, and clinical care of osteoporosis across the menopausal transition
AU - Lizneva, Daria
AU - Yuen, Tony
AU - Sun, Li
AU - Kim, Se min
AU - Atabiekov, Ihor
AU - Munshi, Lubna Bashir
AU - Epstein, Sol
AU - New, Maria
AU - Zaidi, Mone
N1 - Funding Information:
Original research was supported by the National Institutes of Health Grants R01 AR065932 , R01 AR067066 and R01 DK113627 (all to MZ).
Publisher Copyright:
© 2018
PY - 2018/10
Y1 - 2018/10
N2 - Bone loss in women accelerates during perimenopause, and continues into old age. To-date, there has been little progress made in stratifying for fracture risk in premenopausal and early postmenopausal women. Epidemiologic data suggests that changes in serum FSH could predict decrements in bone mass during peri- and postmenopause. In bone, FSH stimulates osteoclast formation by releasing osteoclastogenic cytokines. Here, we address the evidence for bone loss across the menopausal transition, discuss strategies for detection and treatment of early postmenopausal osteoporosis, and describe the role FSH plays in physiology and likely in pathophysiology of early postmenopausal bone loss.
AB - Bone loss in women accelerates during perimenopause, and continues into old age. To-date, there has been little progress made in stratifying for fracture risk in premenopausal and early postmenopausal women. Epidemiologic data suggests that changes in serum FSH could predict decrements in bone mass during peri- and postmenopause. In bone, FSH stimulates osteoclast formation by releasing osteoclastogenic cytokines. Here, we address the evidence for bone loss across the menopausal transition, discuss strategies for detection and treatment of early postmenopausal osteoporosis, and describe the role FSH plays in physiology and likely in pathophysiology of early postmenopausal bone loss.
KW - Bone mineral density
KW - Follicle-stimulating hormone
KW - Menopause
KW - Monoclonal antibodies
KW - Osteoporosis
KW - Polyclonal antibodies
UR - http://www.scopus.com/inward/record.url?scp=85048833772&partnerID=8YFLogxK
U2 - 10.1016/j.matbio.2018.05.001
DO - 10.1016/j.matbio.2018.05.001
M3 - Review article
C2 - 29738833
AN - SCOPUS:85048833772
SN - 0945-053X
VL - 71-72
SP - 70
EP - 81
JO - Matrix Biology
JF - Matrix Biology
ER -