Emerging Biomarkers in Alcohol-associated Hepatitis

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Alcohol-associated hepatitis (AH) is a clinical syndrome of jaundice, abdominal pain, and anorexia due to prolonged heavy alcohol intake. AH is associated with changes in gene expression, cytokines, immune response, and the gut microbiome. There are limited biomarkers to diagnose and prognosticate in AH, but several non-invasive biomarkers are emerging. In this review, clinical risk-stratifying algorithms, promising AH biomarkers like cytokeratin-18 fragments, genetic polymorphisms, and microRNAs will be reviewed.

Original languageEnglish
Pages (from-to)103-115
Number of pages13
JournalJournal of Clinical and Experimental Hepatology
Volume13
Issue number1
DOIs
StatePublished - 1 Jan 2023

Keywords

  • alcohol-associated hepatitis
  • biomarkers
  • cytokines
  • microRNA
  • microbiome

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