TY - JOUR
T1 - Emerging Biomarkers in Alcohol-associated Hepatitis
AU - Im, Gene Y.
N1 - Publisher Copyright:
© 2022 Indian National Association for Study of the Liver
PY - 2023/1/1
Y1 - 2023/1/1
N2 - Alcohol-associated hepatitis (AH) is a clinical syndrome of jaundice, abdominal pain, and anorexia due to prolonged heavy alcohol intake. AH is associated with changes in gene expression, cytokines, immune response, and the gut microbiome. There are limited biomarkers to diagnose and prognosticate in AH, but several non-invasive biomarkers are emerging. In this review, clinical risk-stratifying algorithms, promising AH biomarkers like cytokeratin-18 fragments, genetic polymorphisms, and microRNAs will be reviewed.
AB - Alcohol-associated hepatitis (AH) is a clinical syndrome of jaundice, abdominal pain, and anorexia due to prolonged heavy alcohol intake. AH is associated with changes in gene expression, cytokines, immune response, and the gut microbiome. There are limited biomarkers to diagnose and prognosticate in AH, but several non-invasive biomarkers are emerging. In this review, clinical risk-stratifying algorithms, promising AH biomarkers like cytokeratin-18 fragments, genetic polymorphisms, and microRNAs will be reviewed.
KW - alcohol-associated hepatitis
KW - biomarkers
KW - cytokines
KW - microRNA
KW - microbiome
UR - http://www.scopus.com/inward/record.url?scp=85138206093&partnerID=8YFLogxK
U2 - 10.1016/j.jceh.2022.07.246
DO - 10.1016/j.jceh.2022.07.246
M3 - Review article
AN - SCOPUS:85138206093
SN - 0973-6883
VL - 13
SP - 103
EP - 115
JO - Journal of Clinical and Experimental Hepatology
JF - Journal of Clinical and Experimental Hepatology
IS - 1
ER -