Emerging approaches for targeting metabolic vulnerabilities in malignant glioma

Peter M. Clark; Wilson X. Mai; Timothy F. Cloughesy; David A. Nathanson

doi:10.1007/s11910-015-0613-6

Emerging approaches for targeting metabolic vulnerabilities in malignant glioma

Peter M. Clark, Wilson X. Mai, Timothy F. Cloughesy, David A. Nathanson

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Malignant gliomas are intractable and among the most lethal human malignancies. Like other cancers, metabolic reprogramming is a key feature of glioma and is thought to accommodate the heightened nutrient requirements for tumor cell proliferation, growth, and survival. This metabolic rewiring, driven by oncogenic signaling and molded by the unique environment of the brain, may impose vulnerabilities that could be exploited therapeutically for increased tumor control. In this review, we discuss the prominent metabolic features of malignant glioma, the key pathways regulating glioma metabolism, and the potential therapeutic opportunities for targeting metabolic processes.

Original language	English
Article number	17
Journal	Current Neurology and Neuroscience Reports
Volume	16
Issue number	2
DOIs	https://doi.org/10.1007/s11910-015-0613-6
State	Published - Feb 2016
Externally published	Yes

Keywords

Glioblastoma
Glioma
Glycolysis
Metabolism
Molecular imaging
Targeted therapy

Access to Document

10.1007/s11910-015-0613-6

Cite this

@article{a5a9c7a112904a7895fe6583731e57bc,

title = "Emerging approaches for targeting metabolic vulnerabilities in malignant glioma",

abstract = "Malignant gliomas are intractable and among the most lethal human malignancies. Like other cancers, metabolic reprogramming is a key feature of glioma and is thought to accommodate the heightened nutrient requirements for tumor cell proliferation, growth, and survival. This metabolic rewiring, driven by oncogenic signaling and molded by the unique environment of the brain, may impose vulnerabilities that could be exploited therapeutically for increased tumor control. In this review, we discuss the prominent metabolic features of malignant glioma, the key pathways regulating glioma metabolism, and the potential therapeutic opportunities for targeting metabolic processes.",

keywords = "Glioblastoma, Glioma, Glycolysis, Metabolism, Molecular imaging, Targeted therapy",

author = "Clark, {Peter M.} and Mai, {Wilson X.} and Cloughesy, {Timothy F.} and Nathanson, {David A.}",

note = "Publisher Copyright: {\textcopyright} Springer Science+Business Media New York 2016.",

year = "2016",

month = feb,

doi = "10.1007/s11910-015-0613-6",

language = "English",

volume = "16",

journal = "Current Neurology and Neuroscience Reports",

issn = "1528-4042",

publisher = "Current Medicine Group",

number = "2",

}

TY - JOUR

T1 - Emerging approaches for targeting metabolic vulnerabilities in malignant glioma

AU - Clark, Peter M.

AU - Mai, Wilson X.

AU - Cloughesy, Timothy F.

AU - Nathanson, David A.

N1 - Publisher Copyright: © Springer Science+Business Media New York 2016.

PY - 2016/2

Y1 - 2016/2

N2 - Malignant gliomas are intractable and among the most lethal human malignancies. Like other cancers, metabolic reprogramming is a key feature of glioma and is thought to accommodate the heightened nutrient requirements for tumor cell proliferation, growth, and survival. This metabolic rewiring, driven by oncogenic signaling and molded by the unique environment of the brain, may impose vulnerabilities that could be exploited therapeutically for increased tumor control. In this review, we discuss the prominent metabolic features of malignant glioma, the key pathways regulating glioma metabolism, and the potential therapeutic opportunities for targeting metabolic processes.

AB - Malignant gliomas are intractable and among the most lethal human malignancies. Like other cancers, metabolic reprogramming is a key feature of glioma and is thought to accommodate the heightened nutrient requirements for tumor cell proliferation, growth, and survival. This metabolic rewiring, driven by oncogenic signaling and molded by the unique environment of the brain, may impose vulnerabilities that could be exploited therapeutically for increased tumor control. In this review, we discuss the prominent metabolic features of malignant glioma, the key pathways regulating glioma metabolism, and the potential therapeutic opportunities for targeting metabolic processes.

KW - Glioblastoma

KW - Glioma

KW - Glycolysis

KW - Metabolism

KW - Molecular imaging

KW - Targeted therapy

UR - http://www.scopus.com/inward/record.url?scp=84973494141&partnerID=8YFLogxK

U2 - 10.1007/s11910-015-0613-6

DO - 10.1007/s11910-015-0613-6

M3 - Article

C2 - 26759318

AN - SCOPUS:84973494141

SN - 1528-4042

VL - 16

JO - Current Neurology and Neuroscience Reports

JF - Current Neurology and Neuroscience Reports

IS - 2

M1 - 17

ER -

Emerging approaches for targeting metabolic vulnerabilities in malignant glioma

Abstract

Keywords

Access to Document

Fingerprint

Cite this