Emergency extracorporeal life support for asphyxic status asthmaticus

Mark E. Mikkelsen, Meredith E. Pugh, John H. Hansen-Flaschen, Y. Joseph Woo, Jeffrey S. Sager

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

We report a case of successful use of extracorporeal life support (ECLS) as salvage treatment in an adult with acute, severe, reversible respiratory failure due to asphyxic status asthmaticus. Conventional measures were ineffective to combat the dynamic hyperinflation; the patient had intrinsic positive end-expiratory pressure > 30 cm H2O. We initiated emergency ECLS at the bedside, and after 55 hours of ECLS his respiratory mechanics had markedly improved and he was subsequently weaned off of ECLS and decannulated, without vascular, pulmonary, or neurologic complications. This article reviews the history of ECLS for adult respiratory failure and its application for life-threatening status asthmaticus. This case illustrates the effective use of ECLS for acute respiratory failure due to asphyxic status asthmaticus, and to our knowledge is the first reported case in which the patient's impending cardiopulmonary arrest was due to an unsustainable level of intrinsic positive end-expiratory pressure.

Original languageEnglish
Pages (from-to)1525-1529
Number of pages5
JournalRespiratory Care
Volume52
Issue number11
StatePublished - Nov 2007
Externally publishedYes

Keywords

  • Dynamic hyperinflation
  • Extracorporeal life support
  • Intrinsic positive end-expiratory pressure
  • Mechanical ventilation
  • PEEP
  • Status asthmaticus

Fingerprint

Dive into the research topics of 'Emergency extracorporeal life support for asphyxic status asthmaticus'. Together they form a unique fingerprint.

Cite this