Elevation of ceramide and activation of secretory acid sphingomyelinase in patients with acute coronary syndromes

Wei Pan, Jingjia Yu, Ruizheng Shi, Lei Yan, Tianlun Yang, Yuanjian Li, Zhuohua Zhang, Guolong Yu, Yongping Bai, Edward H. Schuchman, Xingxuan He, Guogang Zhang

Research output: Contribution to journalArticlepeer-review

64 Scopus citations

Abstract

BACKGROUND: Although there are several reported evidences for a pathogenic role of sphingolipid signaling in atherosclerosis, peripheral blood levels of ceramide and secretory acid sphingomyelinase (S-SMase) activity in patients with acute coronary syndromes (ACS) have not been evaluated. METHODS AND RESULTS: A total of 304 CAD patients and 52 healthy individuals were divided into four groups: control group (n=52), stable angina pectoris (SAP) group (n=98), unstable angina pectoris (UAP) group (n=92), and acute myocardial infarction (AMI) group (n=114). Plasma levels of sphingomyelin (SPM) were elevated in patients with UAP and AMI compared with those in the control and SAP participants. Plasma ceramide levels and S-SMase activity in patients with ACS (including UAP and AMI) on day 0 were significantly higher than those in the control and SAP participants. Elevation in plasma ceramide levels in patients with UAP and AMI was sustained until a day after percutaneous coronary intervention or day 7, respectively. Moreover, in patients with UAP, S-SMase activity elevation on day 0 was followed by a gradual decrease toward the SAP range up to a day after percutaneous coronary intervention. In patients with AMI, elevation in S-SMase activity showed a peak on day 3. CONCLUSION: Serial changes in plasma ceramide and S-SMase activity were documented in patients with ACS. These findings provide an insight into the molecular mechanism of plaque destabilization.

Original languageEnglish
Pages (from-to)230-235
Number of pages6
JournalCoronary Artery Disease
Volume25
Issue number3
DOIs
StatePublished - May 2014

Keywords

  • acute coronary syndromes
  • ceramide
  • matrix metalloproteinase
  • secretory acid sphingomyelinase
  • sphingomyelin
  • sphingomyelinase
  • tumor necrosis factor

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