Elevated mitochondrial biogenesis in skeletal muscle is associated with testosterone-induced body weight loss in male mice

Taro Usui, Kazuo Kajita, Toshiko Kajita, Ichiro Mori, Takayuki Hanamoto, Takahide Ikeda, Hideyuki Okada, Koichiro Taguchi, Yoshihiko Kitada, Hiroyuki Morita, Tsutomu Sasaki, Tadahiro Kitamura, Takashi Sato, Itaru Kojima, Tatsuo Ishizuka

Research output: Contribution to journalArticlepeer-review

74 Scopus citations

Abstract

Androgen reduces fat mass, although the underlying mechanisms are unknown. Here, we examined the effect of testosterone on heat production and mitochondrial biogenesis. Testosterone-treated mice exhibited elevated heat production. Treatment with testosterone increased the expression level of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC1α), ATP5B and Cox4 in skeletal muscle, but not that in brown adipose tissue and liver. mRNA levels of genes involved in mitochondrial biogenesis were elevated in skeletal muscle isolated from testosterone-treated male mice, but were down-regulated in androgen receptor deficient mice. These results demonstrated that the testosterone-induced increase in energy expenditure is derived from elevated mitochondrial biogenesis in skeletal muscle.

Original languageEnglish
Pages (from-to)1935-1941
Number of pages7
JournalFEBS Letters
Volume588
Issue number10
DOIs
StatePublished - 21 May 2014
Externally publishedYes

Keywords

  • Androgen receptor deficient mice
  • Mitochondrial biogenesis
  • Skeletal muscle
  • Testosterone

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