Elevated cfDNA after exercise is derived primarily from mature polymorphonuclear neutrophils, with a minor contribution of cardiomyocytes

Ori Fridlich; Ayelet Peretz; Ilana Fox-Fisher; Sheina Pyanzin; Ziv Dadon; Eilon Shcolnik; Ronen Sadeh; Gavriel Fialkoff; Israa Sharkia; Joshua Moss; Ludovica Arpinati; Shachar Nice; Christopher D. Nogiec; Samuel Terkper Ahuno; Rui Li; Eddie Taborda; Sonia Dunkelbarger; Zvi G. Fridlender; Paz Polak; Tommy Kaplan; Nir Friedman; Benjamin Glaser; Ruth Shemer; Naama Constantini; Yuval Dor

doi:10.1016/j.xcrm.2026.102916

Elevated cfDNA after exercise is derived primarily from mature polymorphonuclear neutrophils, with a minor contribution of cardiomyocytes

Ori Fridlich
, Ayelet Peretz
, Ilana Fox-Fisher
, Sheina Pyanzin
, Ziv Dadon
, Eilon Shcolnik
, Ronen Sadeh
, Gavriel Fialkoff
, Israa Sharkia
, Joshua Moss
, Ludovica Arpinati
, Shachar Nice
, Christopher D. Nogiec
, Samuel Terkper Ahuno
, Rui Li
, Eddie Taborda
, Sonia Dunkelbarger
, Zvi G. Fridlender
, Paz Polak
, Tommy Kaplan

Nir Friedman, Benjamin Glaser, Ruth Shemer, Naama Constantini, Yuval Dor

Icahn School of Medicine at Mount Sinai

Research output: Contribution to journal › Comment/debate

Abstract

(Cell Reports Medicine 4, 101074; June 20, 2023) In the original version of this article, an error was introduced by the authors during the assembly of Figure 1C. The pie chart representing the cfDNA tissue origins for Runner 1 at rest was inadvertently duplicated from the data for Runner 2 at rest. This was strictly a figure assembly error—the underlying numerical values and data described were correct. In the corrected Figure 1, panel 1C has been updated to include the correct pie chart for Runner 1 at rest. This correction does not affect data analysis, results, or conclusions of the study.

Original language	English
Article number	102916
Journal	Cell Reports Medicine
DOIs	https://doi.org/10.1016/j.xcrm.2026.102916
State	Accepted/In press - 2026

Access to Document

10.1016/j.xcrm.2026.102916

Cite this

Fridlich, O., Peretz, A., Fox-Fisher, I., Pyanzin, S., Dadon, Z., Shcolnik, E., Sadeh, R., Fialkoff, G., Sharkia, I., Moss, J., Arpinati, L., Nice, S., Nogiec, C. D., Ahuno, S. T., Li, R., Taborda, E., Dunkelbarger, S., Fridlender, Z. G., Polak, P., ... Dor, Y. (Accepted/In press). Elevated cfDNA after exercise is derived primarily from mature polymorphonuclear neutrophils, with a minor contribution of cardiomyocytes. Cell Reports Medicine, Article 102916. https://doi.org/10.1016/j.xcrm.2026.102916

@article{079db4da165c4b3e86bbde434147ac31,

title = "Elevated cfDNA after exercise is derived primarily from mature polymorphonuclear neutrophils, with a minor contribution of cardiomyocytes",

abstract = "(Cell Reports Medicine 4, 101074; June 20, 2023) In the original version of this article, an error was introduced by the authors during the assembly of Figure 1C. The pie chart representing the cfDNA tissue origins for Runner 1 at rest was inadvertently duplicated from the data for Runner 2 at rest. This was strictly a figure assembly error—the underlying numerical values and data described were correct. In the corrected Figure 1, panel 1C has been updated to include the correct pie chart for Runner 1 at rest. This correction does not affect data analysis, results, or conclusions of the study.",

author = "Ori Fridlich and Ayelet Peretz and Ilana Fox-Fisher and Sheina Pyanzin and Ziv Dadon and Eilon Shcolnik and Ronen Sadeh and Gavriel Fialkoff and Israa Sharkia and Joshua Moss and Ludovica Arpinati and Shachar Nice and Nogiec, \{Christopher D.\} and Ahuno, \{Samuel Terkper\} and Rui Li and Eddie Taborda and Sonia Dunkelbarger and Fridlender, \{Zvi G.\} and Paz Polak and Tommy Kaplan and Nir Friedman and Benjamin Glaser and Ruth Shemer and Naama Constantini and Yuval Dor",

note = "Publisher Copyright: {\textcopyright} 2026 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license. http://creativecommons.org/licenses/by-nc-nd/4.0/",

year = "2026",

doi = "10.1016/j.xcrm.2026.102916",

language = "English",

journal = "Cell Reports Medicine",

issn = "2666-3791",

publisher = "Cell Press",

}

Fridlich, O, Peretz, A, Fox-Fisher, I, Pyanzin, S, Dadon, Z, Shcolnik, E, Sadeh, R, Fialkoff, G, Sharkia, I, Moss, J, Arpinati, L, Nice, S, Nogiec, CD, Ahuno, ST, Li, R, Taborda, E, Dunkelbarger, S, Fridlender, ZG, Polak, P, Kaplan, T, Friedman, N, Glaser, B, Shemer, R, Constantini, N & Dor, Y 2026, 'Elevated cfDNA after exercise is derived primarily from mature polymorphonuclear neutrophils, with a minor contribution of cardiomyocytes', Cell Reports Medicine. https://doi.org/10.1016/j.xcrm.2026.102916

TY - JOUR

T1 - Elevated cfDNA after exercise is derived primarily from mature polymorphonuclear neutrophils, with a minor contribution of cardiomyocytes

AU - Fridlich, Ori

AU - Peretz, Ayelet

AU - Fox-Fisher, Ilana

AU - Pyanzin, Sheina

AU - Dadon, Ziv

AU - Shcolnik, Eilon

AU - Sadeh, Ronen

AU - Fialkoff, Gavriel

AU - Sharkia, Israa

AU - Moss, Joshua

AU - Arpinati, Ludovica

AU - Nice, Shachar

AU - Nogiec, Christopher D.

AU - Ahuno, Samuel Terkper

AU - Li, Rui

AU - Taborda, Eddie

AU - Dunkelbarger, Sonia

AU - Fridlender, Zvi G.

AU - Polak, Paz

AU - Kaplan, Tommy

AU - Friedman, Nir

AU - Glaser, Benjamin

AU - Shemer, Ruth

AU - Constantini, Naama

AU - Dor, Yuval

PY - 2026

Y1 - 2026

N2 - (Cell Reports Medicine 4, 101074; June 20, 2023) In the original version of this article, an error was introduced by the authors during the assembly of Figure 1C. The pie chart representing the cfDNA tissue origins for Runner 1 at rest was inadvertently duplicated from the data for Runner 2 at rest. This was strictly a figure assembly error—the underlying numerical values and data described were correct. In the corrected Figure 1, panel 1C has been updated to include the correct pie chart for Runner 1 at rest. This correction does not affect data analysis, results, or conclusions of the study.

AB - (Cell Reports Medicine 4, 101074; June 20, 2023) In the original version of this article, an error was introduced by the authors during the assembly of Figure 1C. The pie chart representing the cfDNA tissue origins for Runner 1 at rest was inadvertently duplicated from the data for Runner 2 at rest. This was strictly a figure assembly error—the underlying numerical values and data described were correct. In the corrected Figure 1, panel 1C has been updated to include the correct pie chart for Runner 1 at rest. This correction does not affect data analysis, results, or conclusions of the study.

UR - https://www.scopus.com/pages/publications/105042273834

U2 - 10.1016/j.xcrm.2026.102916

DO - 10.1016/j.xcrm.2026.102916

M3 - Comment/debate

AN - SCOPUS:105042273834

SN - 2666-3791

JO - Cell Reports Medicine

JF - Cell Reports Medicine

M1 - 102916

ER -

Elevated cfDNA after exercise is derived primarily from mature polymorphonuclear neutrophils, with a minor contribution of cardiomyocytes

Abstract

Access to Document

Fingerprint

Cite this