Elevated alpha1-antichymotrypsin serum levels in a subset of nondemented first-degree relatives of Alzheimer’s disease patients

Larry D. Altstiel; Brian Lawlor; Richard Mohs; James Schmeidler; Arthur Dalton; Pankesh Mehta; Kenneth Davis

doi:10.1159/000106917

Elevated alpha₁-antichymotrypsin serum levels in a subset of nondemented first-degree relatives of Alzheimer’s disease patients

Larry D. Altstiel, Brian Lawlor, Richard Mohs, James Schmeidler, Arthur Dalton, Pankesh Mehta, Kenneth Davis

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

A portion of Alzheimer’s disease (AD) patients have elevated serum levels of the acute phase reactant α_1ˉantichymotrypsin(A1ACT) compared to age-matched controls. We measured serum levels of A1ACT in AD patients, age-matched controls, Down’s syndrome patients, and nondemented first-degree relatives of AD patients. Significantly elevated levels of A1 ACT were found in both AD patients and first-degree-relatives. In AD patients, serum A1ACT concentrations decreased with increasing severity of cognitive impairment. These results may suggest that inflammatory phenomena may be an early component of AD pathophysiology.

Original language	English
Pages (from-to)	17-20
Number of pages	4
Journal	Dementia and Geriatric Cognitive Disorders
Volume	6
Issue number	1
DOIs	https://doi.org/10.1159/000106917
State	Published - 1995

Keywords

Acute phase reactant
Alzheimer’s disease
First degree relative
α-Antichymotrypsin

Access to Document

10.1159/000106917

Cite this

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abstract = "A portion of Alzheimer{\textquoteright}s disease (AD) patients have elevated serum levels of the acute phase reactant α1ˉantichymotrypsin(A1ACT) compared to age-matched controls. We measured serum levels of A1ACT in AD patients, age-matched controls, Down{\textquoteright}s syndrome patients, and nondemented first-degree relatives of AD patients. Significantly elevated levels of A1 ACT were found in both AD patients and first-degree-relatives. In AD patients, serum A1ACT concentrations decreased with increasing severity of cognitive impairment. These results may suggest that inflammatory phenomena may be an early component of AD pathophysiology.",

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AU - Dalton, Arthur

AU - Mehta, Pankesh

AU - Davis, Kenneth

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