Elevated 24-hour mean plasma concentration of FSH in men with cirrhosis of the liver

B. Zumoff, J. Kream, G. W. Strain, J. Levin

Research output: Contribution to journalArticlepeer-review

Abstract

Twenty-four-hour mean plasma concentrations of estradiol, estrone, testosterone, LH and FSH were measured in men with typical alcoholic liver cirrhosis and in 17 age-matched controls. Plasma estradiol levels were markedly elevated in the cirrhotic patients, as has been reported before. Plasma levels of estrone, testosterone and LH did not differ significantly from normal. The most striking finding was marked elevation of the plasma FSH level: the mean value in the cirrhotic group was 19.5 mIU/ml (95% confidence limits, 13-29), more than twice the mean control value, 9.7 mIU/ml (95% confidence limits, 7.0-13) (p<0.0005). This consistent elevation of FSH in cirrhotic men may be due to a deficient testicular secretion of inhibin as a result of alcohol toxicity to the testes.

Original languageEnglish
Pages (from-to)123-125
Number of pages3
JournalThe Journal of reproductive medicine
Volume29
Issue number2
StatePublished - 1984
Externally publishedYes

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