Elektrophysiologische diagnostik des Guillain-Barré-syndroms und der chronisch-inflammatorischen demyelinisierenden polyneuropathie

Translated title of the contribution: Electrodiagnostic examination of Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy

M. J. Hecht, A. Bickel, B. Neundörfer, M. J. Hilz

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Guillain-Barré syndrome (GBS) is the most common cause of acute generalised neuropathy. In Europe, 70% of the GBS patients develop an acute inflammatory demyelinating polyneuropathy (AIDP). Demyelinisation of the nerves accounts for a slowing down in nerve conduction, characterized by prolonged distal motor latencies, decreased nerve conduction velocities, potential dispersion and prolonged F-wave-latency, as well as conduction blocking, characterized by conduction blocks, decreased amplitudes of compound muscle action potentials and diminished recruitment of motor units in the electromyography. Demyelinisation often occurs in distal and proximal nerve regions. Sensory nerve abnormalities are less frequent and occur later in the course of the disease. Acute motor axonal neuropathy (AMAN) and acute motor-sensory axonal neuropathy (AMSAN) are characterized by decreased potential amplitudes and, later in the course of the disease, signs of acute denervation in EMG. In contrast, in chronic demyelinating polyneuropathy (CIDP) there are frequently generalised demyelinations as well as secondary axonal alterations. In the early phase of the disease, electrophysiologic signs may be discrete. According to the American Academy of Electrodiagnostic Medicine (AAEM) the presence of demyelinating nerve conduction study abnormalities in at least two nerves in regions not typical for compressive mononeuropathies, preferably in both an arm and a leg, or a limb and the face are very suspicious for Guillain-Barré syndrome. For a more precise stoging of the course of the diseose, the criteria of the Dutch Guillain-Barré study group (for GBS) and the criteria of Alsbury and Cornblath (for CIDP) are more appropriate.

Translated title of the contributionElectrodiagnostic examination of Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy
Original languageGerman
Pages (from-to)486-490
Number of pages5
Issue number9
StatePublished - 2001
Externally publishedYes


  • CIDP
  • Conduction block
  • Electrodiagnostic examination
  • GBS


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