Electroporation-delivered fluorescent protein biosensors for probing molecular activities in cells without genetic encoding

Chen Sun, Mingxing Ouyang, Zhenning Cao, Sai Ma, Hamzeh Alqublan, Nammalwar Sriranganathan, Yingxiao Wang, Chang Lu

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Fluorescent protein biosensors are typically implemented via genetic encoding which makes the examination of scarce cell samples impractical. By directly delivering the protein form of the biosensor into cells using electroporation, we detected intracellular molecular activity with the sample size down to ∼100 cells with high spatiotemporal resolution.

Original languageEnglish
Pages (from-to)11536-11539
Number of pages4
JournalChemical Communications
Volume50
Issue number78
DOIs
StatePublished - 4 Sep 2014
Externally publishedYes

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