TY - JOUR
T1 - Electrophysiological response during auditory gap detection
T2 - Biomarker for sensory and communication alterations in autism spectrum disorder?
AU - Foss-Feig, Jennifer H.
AU - Stavropoulos, Katherine K.M.
AU - McPartland, James C.
AU - Wallace, Mark T.
AU - Stone, Wendy L.
AU - Key, Alexandra P.
N1 - Funding Information:
This study was supported by a Dennis Weatherstone Predoctoral Fellowship from Autism Speaks to J. H. Foss-Feig and a Marino Autism Research Institute grant to A. P. Key and J. H. Foss-Feig. J. H. Foss-Feig’s effort was also funded in part by a Brain and Behavior Research Foundation NARSAD Young Investigator Award to J. H. Foss-Feig, an Autism Science Foundation Accelerator grant to J. H. Foss-Feig, and the Seaver Foundation. The authors would like to acknowledge Rebecca Johnston, Kimberly Schauder, Caroline Oates, and Holly Black for their assistance with recruitment and data collection. They also would like to thank the children and families who participated in this study. This study was supported by a Dennis Weatherstone Predoctoral Fellowship from Autism Speaks to J. H. Foss-Feig and a Marino Autism Research Institute grant to A. P. Key and J. H. Foss-Feig. J. H. Foss-Feig’s effort was also funded in part by a Brain and Behavior Research Foundation NARSAD Young Investigator Award to J. H. Foss-Feig, an Autism Science Foundation Accelerator grant to J. H. Foss-Feig, and the Seaver Foundation.
Funding Information:
This study was supported by a Dennis Weatherstone Predoctoral Fellowship from Autism Speaks to J. H. Foss-Feig and a Marino Autism Research Institute grant to A. P. Key and J. H. Foss-Feig. J. H. Foss-Feig’s effort was also funded in part by a Brain and Behavior Research Foundation NARSAD Young Investigator Award to J. H. Foss-Feig, an Autism Science Foundation Accelerator grant to J. H. Foss-Feig, and the Seaver Foundation.
Publisher Copyright:
© 2018 Taylor & Francis.
PY - 2018/2/17
Y1 - 2018/2/17
N2 - Sensory symptoms, including auditory processing deficits, are common in autism spectrum disorder (ASD). Processing of temporal aspects of auditory input is understudied; yet, deficits in this domain could contribute to language-related impairments. In children with ASD and well-matched controls, this study examined electrophysiological response to silent gaps in auditory stimuli. Results revealed attenuated amplitude of the P2 event-related potential (ERP) component in ASD. The P2 amplitude reduction was also associated with sensory, language, and diagnostic features. These results suggest that neural response during auditory gap detection is a promising ASD biomarker that could be useful for stratifying subgroups and evaluating treatment response.
AB - Sensory symptoms, including auditory processing deficits, are common in autism spectrum disorder (ASD). Processing of temporal aspects of auditory input is understudied; yet, deficits in this domain could contribute to language-related impairments. In children with ASD and well-matched controls, this study examined electrophysiological response to silent gaps in auditory stimuli. Results revealed attenuated amplitude of the P2 event-related potential (ERP) component in ASD. The P2 amplitude reduction was also associated with sensory, language, and diagnostic features. These results suggest that neural response during auditory gap detection is a promising ASD biomarker that could be useful for stratifying subgroups and evaluating treatment response.
UR - http://www.scopus.com/inward/record.url?scp=85042151766&partnerID=8YFLogxK
U2 - 10.1080/87565641.2017.1365869
DO - 10.1080/87565641.2017.1365869
M3 - Article
C2 - 29436853
AN - SCOPUS:85042151766
SN - 8756-5641
VL - 43
SP - 109
EP - 122
JO - Developmental Neuropsychology
JF - Developmental Neuropsychology
IS - 2
ER -