Electrophysiological response during auditory gap detection: Biomarker for sensory and communication alterations in autism spectrum disorder?

Jennifer H. Foss-Feig, Katherine K.M. Stavropoulos, James C. McPartland, Mark T. Wallace, Wendy L. Stone, Alexandra P. Key

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Sensory symptoms, including auditory processing deficits, are common in autism spectrum disorder (ASD). Processing of temporal aspects of auditory input is understudied; yet, deficits in this domain could contribute to language-related impairments. In children with ASD and well-matched controls, this study examined electrophysiological response to silent gaps in auditory stimuli. Results revealed attenuated amplitude of the P2 event-related potential (ERP) component in ASD. The P2 amplitude reduction was also associated with sensory, language, and diagnostic features. These results suggest that neural response during auditory gap detection is a promising ASD biomarker that could be useful for stratifying subgroups and evaluating treatment response.

Original languageEnglish
Pages (from-to)109-122
Number of pages14
JournalDevelopmental Neuropsychology
Volume43
Issue number2
DOIs
StatePublished - 17 Feb 2018

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