TY - JOUR
T1 - Electrophysiologic changes in heart failure
T2 - Focus on pacemaker channels
AU - Sartiani, Laura
AU - Stillitano, Francesca
AU - Cerbai, Elisabetta
AU - Mugelli, Alessandro
PY - 2009/2
Y1 - 2009/2
N2 - Heart failure is a common clinical syndrome occurring as a result of cardiac overload, injury, and a complex interplay among genetic, neurohormonal, inflammatory, and biochemical factors. Occurrence of arrhythmias in heart failure is largely a consequence of disease-induced electrical remodeling of cardiac myocytes, a phenomenon consisting of alterations of ion channels and the ion-transport function that predispose patients to develop lethal arrhythmias. In most cases, the mechanism is the rapid onset of a ventricular tachyarrhythmia progressing to ventricular fibrillation and hemodynamic compromise. This paper highlights some of the important changes in ion channel expression and function that underlie electrical remodeling of the failing heart. Particular attention will be focused on the presence, features, and pharmacologic modulation of f channels expressed in ventricular cardiac myocytes.
AB - Heart failure is a common clinical syndrome occurring as a result of cardiac overload, injury, and a complex interplay among genetic, neurohormonal, inflammatory, and biochemical factors. Occurrence of arrhythmias in heart failure is largely a consequence of disease-induced electrical remodeling of cardiac myocytes, a phenomenon consisting of alterations of ion channels and the ion-transport function that predispose patients to develop lethal arrhythmias. In most cases, the mechanism is the rapid onset of a ventricular tachyarrhythmia progressing to ventricular fibrillation and hemodynamic compromise. This paper highlights some of the important changes in ion channel expression and function that underlie electrical remodeling of the failing heart. Particular attention will be focused on the presence, features, and pharmacologic modulation of f channels expressed in ventricular cardiac myocytes.
KW - Electrophysiologic remodeling
KW - F channels
KW - Heart failure
UR - http://www.scopus.com/inward/record.url?scp=65249107758&partnerID=8YFLogxK
U2 - 10.1139/Y08-109
DO - 10.1139/Y08-109
M3 - Article
C2 - 19234571
AN - SCOPUS:65249107758
SN - 0008-4212
VL - 87
SP - 84
EP - 90
JO - Canadian Journal of Physiology and Pharmacology
JF - Canadian Journal of Physiology and Pharmacology
IS - 2
ER -